{"id":"W2061303749","doi":"10.1016/j.juro.2010.02.882","title":"1298 THE NOVEL HSP90 INHIBITOR, PF-04929113, INHIBITS AR ACTIVITY AND OSTEOCLASTOGENESIS AND DELAYS CASTRATE RESISTANT LNCAP PROSTATE CANCER TUMOR GROWTH","year":2010,"lang":"en","type":"article","venue":"The Journal of Urology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"LNCaP; DU145; Prostate cancer; Medicine; Cancer research; Androgen receptor; Cancer; Hsp90 inhibitor; Metastasis; Cancer cell; Internal medicine; Hsp90; Heat shock protein; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195126,0.0003976135,0.0004344069,0.0003094896,0.0002561786,0.0003281613,0.000380976,0.0004494182,0.006275579],"category_scores_gemma":[0.0001105663,0.0001999017,0.0004203421,0.0003262805,0.0002205157,0.0002660623,0.0001674856,0.001446712,0.001217663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003490133,"about_ca_system_score_gemma":0.000798494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001414557,"about_ca_topic_score_gemma":0.004580942,"domain_scores_codex":[0.9998268,0.00002509747,0.0000118096,0.00001672113,0.00006222112,0.00005738894],"domain_scores_gemma":[0.9999323,0.00001166181,0.00001182271,0.000006551535,0.000009621946,0.00002802808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003782223,0.004996962,0.001230724,0.0004148678,0.00009777831,0.0001358374,0.00005302949,0.001336927,0.9118533,0.000507581,0.005178862,0.07041179],"study_design_scores_gemma":[0.002596465,0.03529391,0.02341709,0.00006583161,0.0001807263,0.001062984,0.00008685589,0.003593012,0.9128735,0.0002691456,0.02052429,0.00003607698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694843,0.01069636,0.002546456,0.001146249,0.0002256719,0.0004199696,0.001764675,0.0004778594,0.01323839],"genre_scores_gemma":[0.9733332,0.007149303,0.002713241,0.0004744992,0.00005929066,0.0001812532,0.002685047,0.00004080817,0.0133633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006275579,"threshold_uncertainty_score":0.02099383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109247437481027,"score_gpt":0.2627701201606935,"score_spread":0.2518453764125907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}