{"id":"W2061312813","doi":"10.1016/j.bmcl.2010.03.109","title":"Clinical status of duplex RNA","year":2010,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; U.S. Public Health Service; National Institutes of Health; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"RNA; Duplex (building); In vivo; Computational biology; Chemistry; Gene; Genetics; Biology; Biochemistry; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001567623,0.0003869894,0.0004641429,0.0006635329,0.0003438795,0.001549567,0.0005204818,0.001284574,0.006248159],"category_scores_gemma":[0.002545505,0.0001508445,0.000232151,0.0005139009,0.000900696,0.001104548,0.0004171636,0.00122526,0.002861682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001071974,"about_ca_system_score_gemma":0.00129305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003141081,"about_ca_topic_score_gemma":0.0003668537,"domain_scores_codex":[0.999505,0.0001619404,0.00006531998,0.0001089934,0.0001012821,0.00005748855],"domain_scores_gemma":[0.9989141,0.0005821298,0.0001073317,0.00008042727,0.000178862,0.0001372211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002499115,0.0002599175,0.002441821,0.001369998,0.00005597685,0.002094057,0.0001143407,0.0002755285,0.02908994,0.01717321,0.03412627,0.9104998],"study_design_scores_gemma":[0.0006319606,0.00424481,0.005820464,0.0009955975,0.0001832606,0.01435453,0.00007885804,0.0009617124,0.03539453,0.01084191,0.9264321,0.00006030811],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.04737885,0.7918739,0.01033078,0.03634511,0.006596006,0.0002130386,0.0008782191,0.000511933,0.1058722],"genre_scores_gemma":[0.5374137,0.3192269,0.01146713,0.04683302,0.01195129,0.0005716181,0.003198347,0.0002503836,0.06908759],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006248159,"threshold_uncertainty_score":0.02090216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486472190197202,"score_gpt":0.2866050695969998,"score_spread":0.2717403476950278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}