{"id":"W2061312813","doi":"10.1016/j.bmcl.2010.03.109","title":"Clinical status of duplex RNA","year":2010,"lang":"fi","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; U.S. Public Health Service; National Institutes of Health; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"RNA; Duplex (building); In vivo; Computational biology; Chemistry; Gene; Genetics; Biology; Biochemistry; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005218147,0.0005033205,0.0006506062,0.0000409675,0.00008423979,0.00002824443,0.0007895009,0.0008334657,0.001458366],"category_scores_gemma":[0.0006436438,0.0004891276,0.0004187378,0.0001852262,0.001145207,0.000009015943,0.0002868334,0.001061378,0.00005011783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003572592,"about_ca_system_score_gemma":0.0005544605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001062332,"about_ca_topic_score_gemma":0.00002185442,"domain_scores_codex":[0.9964589,0.00008016182,0.00114167,0.0009154271,0.0004686935,0.0009351514],"domain_scores_gemma":[0.9974061,0.00006615837,0.0005407514,0.001127467,0.000227502,0.0006320191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000231291,0.0002110074,0.01061515,0.0002225593,0.0002989298,0.00004875887,0.00007642933,7.215791e-7,0.9649873,0.000003216236,0.01636473,0.006939851],"study_design_scores_gemma":[0.001309196,0.0002648639,0.004937262,0.0001146001,0.0002036454,0.0000808005,0.0002345757,0.00002105715,0.9285223,0.00000265981,0.06383438,0.0004746036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918985,0.002009556,0.0001388589,0.001961732,0.001873389,0.0001690674,0.00012424,0.00001890915,0.001805721],"genre_scores_gemma":[0.9912507,0.001871819,0.000293184,0.001892404,0.003527582,0.000006278578,0.0002780545,0.00006167862,0.000818304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04746965,"threshold_uncertainty_score":0.999756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486472190197202,"score_gpt":0.2866050695969998,"score_spread":0.2717403476950278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}