{"id":"W2061313415","doi":"10.1038/mt.2008.130","title":"A let-7 MicroRNA-sensitive Vesicular Stomatitis Virus Demonstrates Tumor-specific Replication","year":2008,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Discovery Centre; University of Ottawa","funders":"National Cancer Institute","keywords":"Oncolytic virus; Vesicular stomatitis virus; Biology; microRNA; Viral replication; Virus; Cancer cell; Vesicular Stomatitis; Virology; Gene; Cancer; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003199888,0.0003330601,0.0002583531,0.000110648,0.0002604077,0.00004500488,0.0003904281,0.0001682073,0.0000619876],"category_scores_gemma":[0.0000319311,0.0003395785,0.0002274411,0.0002722007,0.0002974597,0.000008661106,0.00006799922,0.000194808,0.0001498749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004419051,"about_ca_system_score_gemma":0.000136458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004713952,"about_ca_topic_score_gemma":0.00002246981,"domain_scores_codex":[0.9976395,0.0003149963,0.0003154257,0.0008601251,0.0003734351,0.0004964777],"domain_scores_gemma":[0.9981334,0.00001602982,0.0001261351,0.001335423,0.000228369,0.0001606726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009429342,0.0001427092,0.0001166109,0.000003740745,0.0001467055,0.0002425234,0.0001411602,0.00006461534,0.9892266,0.00003339445,0.001290262,0.00764868],"study_design_scores_gemma":[0.001132345,0.001454797,0.001023422,0.000009962948,0.000005010054,0.0002809549,0.00004134566,0.00004096373,0.9639969,0.00006004404,0.03157865,0.0003755891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882725,0.007901497,0.002155557,0.0003951266,0.00006986425,0.0005746781,0.00003214406,0.00006290431,0.0005357123],"genre_scores_gemma":[0.9923202,0.004254819,0.0009322243,0.001624036,0.000174237,0.0001116181,0.0002276656,0.00009871149,0.0002564563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03028838,"threshold_uncertainty_score":0.9999056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02106723143707975,"score_gpt":0.2718457248246023,"score_spread":0.2507784933875226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}