{"id":"W2061318708","doi":"10.1073/pnas.1221740110","title":"CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":518,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute","keywords":"Glycolysis; Bioenergetics; Oxidative phosphorylation; Cell biology; Mitochondrion; Biology; Anaerobic glycolysis; Hexokinase; Effector; CD8; Biochemistry; Metabolism; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007446182,0.0001142625,0.0001673859,0.0001378301,0.0002745489,0.00002038498,0.0005214938,0.0001428241,0.0008845047],"category_scores_gemma":[0.0002299044,0.00006863051,0.0001161349,0.0002077763,0.001205792,0.0004598511,0.0001187006,0.0002320615,0.00005169022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003813465,"about_ca_system_score_gemma":0.00002168008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002753169,"about_ca_topic_score_gemma":1.691869e-7,"domain_scores_codex":[0.9990922,0.0000249279,0.0003060971,0.0002357514,0.0001672212,0.0001738316],"domain_scores_gemma":[0.9991241,0.0002246983,0.0003791817,0.00001407518,0.0002457861,0.00001221883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002212686,0.00004895329,0.0008415911,0.00002919607,0.00002439944,6.318024e-10,0.0002473238,0.000008216248,0.9906647,0.001907789,0.005316812,0.0008888508],"study_design_scores_gemma":[0.0001861783,0.00006983009,0.01058747,0.00004242635,0.000008389985,0.000008375728,0.002262388,0.00006444134,0.977073,0.006572889,0.003045528,0.00007907055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694841,0.0006886108,0.000002178175,0.003021939,0.0003893904,0.0002972748,0.000005957639,0.00002619393,0.02608438],"genre_scores_gemma":[0.996219,0.0001320873,0.000105276,0.0003954358,0.00002120994,0.00001704743,6.156148e-7,0.000003838202,0.003105443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02673497,"threshold_uncertainty_score":0.9684706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03625292155781022,"score_gpt":0.2659562010021493,"score_spread":0.2297032794443391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}