{"id":"W2061346255","doi":"10.1021/jm034206x","title":"Discovery of Small-Molecule Inhibitors of the ATPase Activity of Human Papillomavirus E1 Helicase","year":2003,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Helicase; Chemistry; ATPase; Human papillomavirus; Small molecule; Acetic acid; Lead compound; DNA; RNA Helicase A; Enzyme; Virology; Biochemistry; RNA; In vitro; Gene; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002158459,0.0005111105,0.0005672627,0.0007497436,0.0001638134,0.0003372049,0.0002895973,0.0002702972,0.001924094],"category_scores_gemma":[0.0002471711,0.0002567608,0.0002987222,0.0003051272,0.0001608682,0.0001783349,0.0001831059,0.0005480857,0.0004877683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003367027,"about_ca_system_score_gemma":0.0004711014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006307512,"about_ca_topic_score_gemma":0.003225639,"domain_scores_codex":[0.9999198,0.00001231504,0.000005156123,0.0000118277,0.0000283169,0.00002258117],"domain_scores_gemma":[0.9999026,0.00002468224,0.00001580151,0.000005342461,0.00002176725,0.00002969785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008530908,0.0007455273,0.0009939994,0.000586792,0.0001160956,0.0008825445,0.00009700202,0.002179289,0.906474,0.002323493,0.002519262,0.08222892],"study_design_scores_gemma":[0.002447276,0.01187066,0.006489042,0.0001561964,0.0003155551,0.001694989,0.00008100997,0.004103737,0.909785,0.00114422,0.0618545,0.00005775823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9265671,0.04023034,0.01405955,0.001232877,0.0002959582,0.0009906614,0.003001955,0.0005657434,0.0130558],"genre_scores_gemma":[0.9381182,0.03438659,0.01020384,0.0004705115,0.000109188,0.0003321945,0.003220786,0.00003832349,0.01312044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001924094,"threshold_uncertainty_score":0.006436765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02931996501666418,"score_gpt":0.3261353026528311,"score_spread":0.296815337636167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}