{"id":"W2061380383","doi":"10.1038/ncb2919","title":"Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation","year":2014,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"AMPK; Cell biology; Protein kinase A; Secretion; Ubiquitin ligase; Regulator; Activator (genetics); AMP-activated protein kinase; Biology; Kinase; Chemistry; Ubiquitin; Endocrinology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002027075,0.0001132173,0.0003008076,0.00009038074,0.00003814132,0.000002660635,0.00007909348,0.0003225857,0.0004617186],"category_scores_gemma":[0.0002036742,0.0000725607,0.00008184207,0.0001963578,0.0001115311,0.00001521186,0.00003109201,0.0003834378,0.00005082081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003637184,"about_ca_system_score_gemma":0.00005050248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000036323,"about_ca_topic_score_gemma":0.00001168905,"domain_scores_codex":[0.999145,0.0001539577,0.0002314093,0.000192125,0.0001094736,0.0001680913],"domain_scores_gemma":[0.9991785,0.0003289911,0.0001157777,0.000248916,0.00008129427,0.00004654851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001152736,0.000143691,0.2410791,0.00005500048,0.00001231035,1.950328e-7,0.0000440445,0.0000246087,0.7545227,0.00207565,0.001371373,0.000556026],"study_design_scores_gemma":[0.003171068,0.0003252739,0.8171394,0.00004265154,0.0000860177,0.000006100706,0.0001319866,0.003487453,0.1202167,0.002103384,0.05315477,0.0001351977],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9295051,0.0005987716,0.00004034006,0.000455327,0.0003151273,0.0002134175,0.000007398477,0.00002168972,0.06884288],"genre_scores_gemma":[0.9968237,0.00001336233,0.0002705792,0.001765163,0.0001439617,0.000009008142,0.0001256029,0.000008608132,0.0008400572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.634306,"threshold_uncertainty_score":0.5055495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00981963879590873,"score_gpt":0.2305509051940608,"score_spread":0.2207312663981521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}