{"id":"W2061383773","doi":"10.1038/onc.2012.6","title":"Targeting tumor cell metabolism with statins","year":2012,"lang":"en","type":"review","venue":"Oncogene","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":238,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"University of Pennsylvania","keywords":"Mevalonate pathway; Biology; Context (archaeology); Statin; Carcinogenesis; Cancer; Mevalonic acid; Cancer research; HMG-CoA reductase; Metabolic pathway; Cholesterol; Bioinformatics; Reductase; Metabolism; Enzyme; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000520119,0.001131803,0.001760936,0.001540858,0.000268228,0.0009428266,0.0008728897,0.001047162,0.001765201],"category_scores_gemma":[0.0005252711,0.0003639665,0.0004935788,0.001542045,0.0004961378,0.0009385206,0.0006231091,0.002503196,0.001864153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007872659,"about_ca_system_score_gemma":0.0007900587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001255959,"about_ca_topic_score_gemma":0.003105676,"domain_scores_codex":[0.9998605,0.00001779627,0.00002004555,0.00002652881,0.00005385849,0.00002120999],"domain_scores_gemma":[0.9998369,0.00006012202,0.00002493542,0.000008136833,0.00004714497,0.00002270796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002375382,0.0001523853,0.0001602712,0.0088754,0.0001265302,0.000249693,0.00002910979,0.0006156716,0.007127464,0.00578392,0.04345515,0.9331869],"study_design_scores_gemma":[0.00007062415,0.000118355,0.0006002869,0.001034702,0.0001699627,0.0008784385,0.00002613435,0.0002007178,0.002608845,0.00207185,0.9921938,0.0000262166],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001936476,0.9977868,0.0003973215,0.000382741,0.0002625097,0.000006440772,0.00003933628,0.0000170487,0.0009142113],"genre_scores_gemma":[0.0009375604,0.9974424,0.0003433333,0.0002193121,0.0001561244,0.00001077541,0.00006167626,0.000002670263,0.0008260798],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001765201,"threshold_uncertainty_score":0.005905151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02072482979029893,"score_gpt":0.2828809169422277,"score_spread":0.2621560871519288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}