{"id":"W2061398775","doi":"10.1158/1538-7445.am2014-1224","title":"Abstract 1224: A patient derived xenograft (PDX) platform for development of next generation KIT kinase inhibitors in imatinib-resistant gastrointestinal stromal tumors (GIST)","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Workplace Health, Safety and Compensation Commission","funders":"","keywords":"GiST; Imatinib; Medicine; Dasatinib; Stromal tumor; Imatinib mesylate; Cancer; Oncology; Cancer research; Drug resistance; Internal medicine; Stromal cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005098536,0.0004609164,0.0003105723,0.0003902073,0.000251625,0.0006636366,0.0004051005,0.0006053246,0.005926224],"category_scores_gemma":[0.0001917671,0.000237619,0.0003535778,0.0001968488,0.00019897,0.0005190161,0.0002962753,0.001306112,0.002067649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002560059,"about_ca_system_score_gemma":0.0002719689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004554563,"about_ca_topic_score_gemma":0.0005915778,"domain_scores_codex":[0.9997517,0.0000467243,0.00002466273,0.00005053841,0.00009603538,0.00003024482],"domain_scores_gemma":[0.9998521,0.00002627393,0.00002840206,0.00003043199,0.00002134284,0.00004151365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002911206,0.0003330461,0.000477478,0.00006144498,0.00001639274,0.0002327308,0.00003492203,0.0005154641,0.9909766,0.0006698986,0.002120388,0.004270494],"study_design_scores_gemma":[0.0001880412,0.004109751,0.004490055,0.00002163207,0.00005741975,0.002781979,0.00006849755,0.005618026,0.9545009,0.000288179,0.02785106,0.00002439104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9288343,0.002598662,0.03499002,0.00149705,0.0007369015,0.0008125922,0.01441727,0.001563084,0.01455008],"genre_scores_gemma":[0.9293411,0.002910176,0.0346748,0.0004259845,0.00006933484,0.0007287447,0.01278485,0.0002628259,0.01880213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005926224,"threshold_uncertainty_score":0.01982516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1429513867677306,"score_gpt":0.38339462369096,"score_spread":0.2404432369232294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}