{"id":"W2061407675","doi":"10.1074/jbc.m206978200","title":"Structure of Arterivirus nsp4","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"Basic Energy Sciences; National Center for Research Resources; Canadian Institutes of Health Research; Office of Science; Alberta Heritage Foundation for Medical Research; National Institutes of Health; University of Alberta; Fondation pour la Recherche Médicale; U.S. Department of Energy","keywords":"Arterivirus; Biology; Oxyanion hole; Polyproteins; RNA; Catalytic triad; RNA-dependent RNA polymerase; Gene; Virology; Chymotrypsin; Recombinant DNA; Molecular biology; Genetics; Biochemistry; Peptide sequence; Enzyme; Trypsin; Active site","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006419949,0.0000933612,0.0002324443,0.000003959751,0.00006335381,0.000008552787,0.000184812,0.0001253046,0.003785707],"category_scores_gemma":[0.0001444328,0.00002841929,0.000151612,0.0001306343,0.0001301221,0.00003792973,0.00004772627,0.0001785954,0.000006528078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000151619,"about_ca_system_score_gemma":0.0000015486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003345076,"about_ca_topic_score_gemma":0.000002244807,"domain_scores_codex":[0.9993217,0.00002194627,0.0003177685,0.00009045772,0.0001202969,0.000127839],"domain_scores_gemma":[0.9994026,0.0001087212,0.0002933269,0.00002785948,0.0001090612,0.00005846503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001854822,0.00006887336,0.01346808,0.000004377478,0.00002072023,0.000005320202,0.00001167447,0.000001006331,0.9801781,0.000006777357,0.0006666754,0.005549817],"study_design_scores_gemma":[0.0002115547,0.0008435583,0.1148572,0.00003395309,0.00002366461,0.0002584534,0.0002366226,0.000008545166,0.8641021,0.0008005763,0.01842697,0.0001968228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970261,0.0006261606,0.000001727992,0.0002048147,0.00005172658,0.0000206622,0.00002747958,0.000009603845,0.00203174],"genre_scores_gemma":[0.9991896,0.0002469052,0.00009760985,0.00005600505,0.0003334951,2.798298e-7,0.000001373353,3.335483e-7,0.00007439454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1160761,"threshold_uncertainty_score":0.997125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03874798161435553,"score_gpt":0.2213411127737625,"score_spread":0.182593131159407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}