{"id":"W2061409025","doi":"10.1016/j.ymgme.2008.03.010","title":"Partial trypsin digestion as an indicator of mis-folding of mutant alanine:glyoxylate aminotransferase and chaperone effects of specific ligands. Study of a spectrum of missense mutants","year":2008,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Kidney Stones and Urolithiasis Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Children's & Women's Health Centre of British Columbia","funders":"","keywords":"Biochemistry; Mutant; Trypsin; Alanine; Chemistry; Molecular biology; Chaperone (clinical); Protease; Biology; Enzyme; Mutant protein; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002389678,0.0003582435,0.0002203331,0.0002508357,0.0001378702,0.0001563282,0.0002047488,0.0003763725,0.0008983159],"category_scores_gemma":[0.0002231888,0.000136831,0.0002009128,0.0002890881,0.0002351457,0.000111626,0.0001443533,0.0003986938,0.0001651369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001646605,"about_ca_system_score_gemma":0.0001390117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005024814,"about_ca_topic_score_gemma":0.0006403496,"domain_scores_codex":[0.9998186,0.00005197165,0.0000279736,0.00003114467,0.0000331829,0.00003710483],"domain_scores_gemma":[0.9997703,0.00006590361,0.00006132432,0.0000267687,0.00002228112,0.00005333307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001722005,0.00002054573,0.0002188652,0.0000112836,0.000007377632,0.00007172574,0.000006621426,0.00001897762,0.9992362,0.00002580785,0.00001173577,0.0001986794],"study_design_scores_gemma":[0.00001712238,0.0004192935,0.007308436,0.00000279674,0.00002189968,0.001216533,0.00003184308,0.0005125048,0.9899609,0.00003239745,0.0004723518,0.00000380835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969357,0.0006354452,0.001588411,0.00005526132,0.00002206888,0.00001747777,0.0002618095,0.00003074533,0.000453003],"genre_scores_gemma":[0.9951141,0.0004681659,0.002988583,0.00003811387,0.00000494123,0.00002282025,0.0005629694,0.00002280667,0.0007775347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008983159,"threshold_uncertainty_score":0.003005147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01015930665454958,"score_gpt":0.244284004497468,"score_spread":0.2341246978429184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}