{"id":"W2061461595","doi":"10.1016/j.chembiol.2013.03.001","title":"Niemann-Pick NPC1: Sterols to the Rescue and Beyond","year":2013,"lang":"en","type":"letter","venue":"Chemistry & Biology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"NPC1; Endosome; Niemann–Pick disease; Niemann–Pick disease, type C; Sterol; Biology; Computational biology; Cell biology; Biochemistry; Cholesterol; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002129782,0.0008973659,0.001536477,0.0004828011,0.001951955,0.00211782,0.001171517,0.02370199,0.004186396],"category_scores_gemma":[0.01072549,0.000336979,0.001013984,0.0003478679,0.003036924,0.002813991,0.001565288,0.02369771,0.004120842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003005683,"about_ca_system_score_gemma":0.002116882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002021544,"about_ca_topic_score_gemma":0.002648144,"domain_scores_codex":[0.9986897,0.0004035723,0.000154273,0.0001355725,0.0004720466,0.0001448497],"domain_scores_gemma":[0.9974004,0.001505848,0.0001375275,0.0001407281,0.0004241387,0.0003914036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001690163,0.00004633096,0.0001923081,0.00009950557,0.00002047125,0.002471551,0.00004755952,0.00009694049,0.0004577308,0.00892326,0.9625796,0.02489584],"study_design_scores_gemma":[0.0002660992,0.00009803976,0.0002957395,0.0001629033,0.00002850723,0.002345138,0.0001179676,0.0003518803,0.0005791862,0.03264613,0.963065,0.00004338862],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003523451,0.009161022,0.0002313545,0.9620196,0.02578539,0.00001029559,0.00004558999,0.0000484643,0.002345864],"genre_scores_gemma":[0.01151195,0.01806152,0.0007822408,0.8297672,0.1255524,0.00007868448,0.00006833411,0.00004460074,0.01413311],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02370199,"threshold_uncertainty_score":0.02180785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02046836979569763,"score_gpt":0.2942154082722923,"score_spread":0.2737470384765947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}