{"id":"W2061480585","doi":"10.1016/j.bmcl.2010.10.039","title":"Synthesis of d- and l-tyrosine-chlorambucil analogs active against breast cancer cell lines","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chlorambucil; Chemistry; Moiety; Tyrosine; Stereochemistry; Biological activity; In vitro; Cell culture; Breast cancer; Cancer research; Cancer; Cancer cell lines; Cancer cell; Chemotherapy; Biochemistry; Internal medicine; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001214127,0.0002508054,0.0003285891,0.00001751762,0.00006017834,0.00001438289,0.0002475451,0.0002182306,0.000308166],"category_scores_gemma":[0.0001356056,0.0002132394,0.0001347903,0.0001215042,0.0003257893,0.00000663452,0.0001037263,0.0001926105,0.000001591432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002283557,"about_ca_system_score_gemma":0.00006594244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001730187,"about_ca_topic_score_gemma":0.00003427526,"domain_scores_codex":[0.9987484,0.00001569881,0.0002893938,0.0004617413,0.0002185462,0.0002662806],"domain_scores_gemma":[0.9991344,0.00004514511,0.0001857017,0.0003530922,0.00009378738,0.0001878745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006430779,0.00006907724,0.002392952,0.0001136018,0.0001065039,0.000003942287,0.00002001665,0.000001068107,0.9908072,4.039723e-7,0.0009194888,0.005501419],"study_design_scores_gemma":[0.0002806078,0.000008315058,0.002924133,0.00005140988,0.0001597583,0.0000245495,0.0001215506,0.00002547969,0.9951035,0.000001448384,0.001063608,0.000235606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964265,0.0005791502,0.00001955889,0.002342503,0.00005623191,0.00005157742,0.000139344,0.00001195496,0.0003731747],"genre_scores_gemma":[0.997796,0.0006741846,0.00009936529,0.0005630893,0.0007099759,0.00001357527,0.0000520996,0.00002833145,0.00006340366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005265813,"threshold_uncertainty_score":0.8695651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004271944624688346,"score_gpt":0.2113580998809005,"score_spread":0.2070861552562121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}