{"id":"W2061480585","doi":"10.1016/j.bmcl.2010.10.039","title":"Synthesis of d- and l-tyrosine-chlorambucil analogs active against breast cancer cell lines","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chlorambucil; Chemistry; Moiety; Tyrosine; Stereochemistry; Biological activity; In vitro; Cell culture; Breast cancer; Cancer research; Cancer; Cancer cell lines; Cancer cell; Chemotherapy; Biochemistry; Internal medicine; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144943,0.000310942,0.0003259513,0.0002061424,0.0001797628,0.0001708167,0.0003572914,0.0002255621,0.001793914],"category_scores_gemma":[0.000123688,0.0001630858,0.0001877647,0.0002307079,0.0001073986,0.0001414511,0.0001681,0.0003695317,0.0003785295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002581986,"about_ca_system_score_gemma":0.0002720537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007488522,"about_ca_topic_score_gemma":0.001166009,"domain_scores_codex":[0.9999361,0.00001148977,0.000007674833,0.00001023502,0.0000109526,0.00002351484],"domain_scores_gemma":[0.9999348,0.00001103184,0.0000130683,0.000009647484,0.000009632784,0.00002175554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004244653,0.00008745918,0.0001074371,0.0001490144,0.00001308573,0.0001967813,0.00003382403,0.000697726,0.9878889,0.0003269973,0.0002933422,0.009781147],"study_design_scores_gemma":[0.0002156244,0.001127135,0.0009247447,0.00001072726,0.00003357681,0.0003335317,0.0000168308,0.0005854677,0.9877571,0.00005786601,0.008926892,0.00001052065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720777,0.005461794,0.008579913,0.0002751438,0.0001255373,0.0004911261,0.001753939,0.0002529448,0.01098194],"genre_scores_gemma":[0.9899698,0.002179383,0.004503876,0.0001059588,0.00001778818,0.0001409731,0.001010844,0.00001944238,0.002051944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793914,"threshold_uncertainty_score":0.006001234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004271944624688346,"score_gpt":0.2113580998809005,"score_spread":0.2070861552562121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}