{"id":"W2061484408","doi":"10.1073/pnas.160016897","title":"Down-regulation of p21 <sup>WAF1/CIP1</sup> or p27 <sup>Kip1</sup> abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells","year":2000,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Antiestrogen; Cyclin-dependent kinase; Cyclin-dependent kinase 2; Cyclin E; Cell cycle; Cancer research; Tamoxifen; Cyclin-dependent kinase 4; Chemistry; Kinase; Cyclin; Cell cycle checkpoint; Estrogen receptor; Cyclin D; Cyclin A; Cell biology; Biology; Breast cancer; Cell; Internal medicine; Cancer; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005926795,0.0001918568,0.0002448852,0.0001623759,0.0001714841,0.00002230807,0.0006593648,0.0002861238,0.0001094643],"category_scores_gemma":[0.00005886842,0.0001326913,0.0001213658,0.0007144377,0.0008022426,0.000058533,0.0001052229,0.0002074375,0.000003530128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002981715,"about_ca_system_score_gemma":0.00009215069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000687279,"about_ca_topic_score_gemma":5.867261e-7,"domain_scores_codex":[0.9981114,0.00002219369,0.0004994058,0.0003822587,0.0007003281,0.0002844331],"domain_scores_gemma":[0.9992654,0.00004566471,0.0003808234,0.00002696783,0.0002146298,0.00006656398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001137285,0.0001460806,0.009233396,0.0000872314,0.00003360381,3.780545e-8,0.0002072936,0.02023205,0.968959,0.0001776096,0.0005032051,0.0003068084],"study_design_scores_gemma":[0.0006586043,0.0001492119,0.02536753,0.0001413847,0.00002472776,0.000009661229,0.0001770915,0.006614801,0.965964,0.0005690999,0.0001557553,0.0001681294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969962,0.0005242415,1.871264e-7,0.0004208203,0.0000136983,0.0002696156,0.0001000951,0.000008646386,0.001666546],"genre_scores_gemma":[0.9988618,0.0003642275,0.0001837829,0.00008215995,0.0001207347,0.00001661314,0.000007011128,0.00001170908,0.0003519189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01613414,"threshold_uncertainty_score":0.5410996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009909282251484068,"score_gpt":0.2646525587596603,"score_spread":0.2547432765081762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}