{"id":"W2061484408","doi":"10.1073/pnas.160016897","title":"Down-regulation of p21 <sup>WAF1/CIP1</sup> or p27 <sup>Kip1</sup> abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells","year":2000,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Antiestrogen; Cyclin-dependent kinase; Cyclin-dependent kinase 2; Cyclin E; Cell cycle; Cancer research; Tamoxifen; Cyclin-dependent kinase 4; Chemistry; Kinase; Cyclin; Cell cycle checkpoint; Estrogen receptor; Cyclin D; Cyclin A; Cell biology; Biology; Breast cancer; Cell; Internal medicine; Cancer; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000891813,0.0003013728,0.0001899518,0.0002009877,0.0001556555,0.0002159243,0.0001525816,0.0001387738,0.001413427],"category_scores_gemma":[0.00009557382,0.0001171637,0.0001347895,0.0001332489,0.0001734302,0.000111707,0.00009168054,0.000327342,0.0005665808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002587301,"about_ca_system_score_gemma":0.0002508367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001207319,"about_ca_topic_score_gemma":0.001948723,"domain_scores_codex":[0.9999157,0.0000109278,0.000007363586,0.00001126363,0.0000272337,0.00002750232],"domain_scores_gemma":[0.9999437,0.0000123868,0.00001154824,0.000008592986,0.000008364658,0.00001543146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001573039,0.00005751263,0.0001159769,0.00003144212,0.000006100055,0.00005058164,0.00000871229,0.00007059711,0.9973933,0.000131614,0.0001093156,0.001867566],"study_design_scores_gemma":[0.00001804864,0.0002892117,0.002655021,0.000003223271,0.00001239708,0.0001969446,0.00001286239,0.0005130736,0.9914718,0.00003174187,0.004793232,0.000002369291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925358,0.002685198,0.001202252,0.0001677688,0.00004805199,0.00003022401,0.0006026883,0.000100975,0.002627012],"genre_scores_gemma":[0.9894749,0.002815278,0.001093259,0.00006139372,0.00002557704,0.00004009974,0.001301158,0.00002465488,0.005163757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001413427,"threshold_uncertainty_score":0.004728436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009909282251484068,"score_gpt":0.2646525587596603,"score_spread":0.2547432765081762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}