{"id":"W2061502176","doi":"10.3892/ijmm.17.3.437","title":"Plasminogen activator inhibitor-1 is locked in active conformation and polymerizes upon binding ligands neutralizing its activity","year":2006,"lang":"en","type":"article","venue":"International Journal of Molecular Medicine","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Micropharma (Canada)","funders":"National Cancer Institute; National Institutes of Health; Philipps-Universität Marburg","keywords":"Serpin; Proteolysis; Chemistry; Plasminogen activator inhibitor-1; Active site; Plasminogen activator; Steric effects; Biochemistry; Binding site; Stereochemistry; Tissue plasminogen activator; Enzyme; Molecular biology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009534378,0.0002589365,0.0002675185,0.0001391939,0.0001844688,0.0004163123,0.0004030469,0.0003072614,0.00304778],"category_scores_gemma":[0.0002954567,0.0001859775,0.0002885256,0.0001782232,0.0003351037,0.0003436625,0.0001806608,0.0006879757,0.0008510026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003536931,"about_ca_system_score_gemma":0.0003194471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007283,"about_ca_topic_score_gemma":0.0005005605,"domain_scores_codex":[0.9998661,0.00001280566,0.000003545316,0.00003856643,0.00004942987,0.00002948835],"domain_scores_gemma":[0.9999056,0.00002657872,0.00003791353,0.000005759861,0.00001047901,0.0000136949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002343556,0.00006659291,0.001505533,0.0002425221,0.00005131939,0.0001213935,0.00004083745,0.004243468,0.9771075,0.001538842,0.0004311079,0.01441644],"study_design_scores_gemma":[0.00004538627,0.0006255414,0.00394442,0.00001749501,0.00003550724,0.0002790606,0.00004283085,0.01744124,0.9656641,0.0007773797,0.01109214,0.00003494945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9475445,0.005571245,0.03756566,0.000254111,0.00009720464,0.00005935629,0.0004321974,0.0004773687,0.007998277],"genre_scores_gemma":[0.9891405,0.001840187,0.005176558,0.00006916648,0.0000107921,0.00004177238,0.0003401373,0.00002997939,0.003350886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00304778,"threshold_uncertainty_score":0.01019591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0086142845725818,"score_gpt":0.2581750709367606,"score_spread":0.2495607863641788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}