{"id":"W2061502176","doi":"10.3892/ijmm.17.3.437","title":"Plasminogen activator inhibitor-1 is locked in active conformation and polymerizes upon binding ligands neutralizing its activity","year":2006,"lang":"en","type":"article","venue":"International Journal of Molecular Medicine","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Micropharma (Canada)","funders":"National Cancer Institute; National Institutes of Health; Philipps-Universität Marburg","keywords":"Serpin; Proteolysis; Chemistry; Plasminogen activator inhibitor-1; Active site; Plasminogen activator; Steric effects; Biochemistry; Binding site; Stereochemistry; Tissue plasminogen activator; Enzyme; Molecular biology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212443,0.0001418115,0.0001877167,0.000239349,0.00002906063,0.00001607391,0.0001569711,0.0001137542,0.00001655927],"category_scores_gemma":[0.00009039963,0.0001237465,0.00006312289,0.00007556262,0.00003906838,0.00004498452,0.00005931266,0.0001605996,0.000001147159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004924915,"about_ca_system_score_gemma":0.00006941136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004525439,"about_ca_topic_score_gemma":0.00000564927,"domain_scores_codex":[0.9989445,0.00003663463,0.0003503094,0.0001480268,0.0003759238,0.0001445667],"domain_scores_gemma":[0.9992948,0.00001493085,0.0003482286,0.00007450714,0.0001965746,0.00007094003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003986905,0.00004560218,0.0001811304,0.000007867668,0.00007379553,0.00006154499,0.0001041569,0.00001357712,0.996343,0.0001032727,0.0002501342,0.002417182],"study_design_scores_gemma":[0.001924897,0.0003593924,0.0008291305,0.000186662,0.00001930581,0.0001763931,0.0001111958,0.00008407922,0.99507,0.0001178638,0.001006738,0.0001143393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960626,0.0009185072,0.0009807693,0.001249984,0.000391577,0.00009996973,0.00001232655,0.000003397589,0.0002808202],"genre_scores_gemma":[0.9986659,0.0002345393,0.00008605252,0.0003257484,0.0006142059,0.000003501935,0.00002630585,0.00001337178,0.00003036427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002603261,"threshold_uncertainty_score":0.5046237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0086142845725818,"score_gpt":0.2581750709367606,"score_spread":0.2495607863641788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}