{"id":"W2061514779","doi":"10.1182/blood-2005-06-2202","title":"Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":475,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Canadian Blood Services","keywords":"Innate immune system; TLR4; TLR2; TLR9; Platelet; Biology; Lipopolysaccharide; Tumor necrosis factor alpha; Toll-like receptor; Immunology; In vivo; Receptor; Cytokine; Immune system; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003132363,0.0003271199,0.0002785276,0.0003295697,0.0001189924,0.0003537423,0.0001477803,0.0003232525,0.0009486733],"category_scores_gemma":[0.0003103864,0.000199514,0.0001776447,0.0001884395,0.0002533773,0.000207512,0.0001386804,0.000727867,0.0004261565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000224186,"about_ca_system_score_gemma":0.0001178702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001394661,"about_ca_topic_score_gemma":0.0001461396,"domain_scores_codex":[0.9996998,0.0001267628,0.00002403965,0.00003062944,0.00004671702,0.00007197387],"domain_scores_gemma":[0.9997272,0.00007101116,0.00008950144,0.00003720898,0.00001980771,0.00005532971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009867497,0.00007971186,0.0001923055,0.00003520161,0.000006963617,0.00009978029,0.00001681995,0.00004827167,0.997276,0.00007585123,0.000051466,0.001130789],"study_design_scores_gemma":[0.0001287661,0.002021577,0.005124778,0.0000109011,0.00004687684,0.0004172576,0.00003359585,0.00122084,0.9898573,0.00009659694,0.001036486,0.000005107245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953217,0.001616765,0.001724699,0.00009874741,0.00003450542,0.00003266315,0.0001798205,0.00005370704,0.0009375222],"genre_scores_gemma":[0.9957694,0.001160446,0.001054569,0.00006998712,0.0000412924,0.00007034203,0.0004654216,0.00001602946,0.001352475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009486733,"threshold_uncertainty_score":0.00317359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229951962769767,"score_gpt":0.2290176330644982,"score_spread":0.2167181134368006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}