{"id":"W2061538135","doi":"10.1371/journal.pone.0017611","title":"Novel Strains of Mice Deficient for the Vesicular Acetylcholine Transporter: Insights on Transcriptional Regulation and Control of Locomotor Behavior","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Vesicular acetylcholine transporter; Cholinergic; Choline acetyltransferase; Acetylcholine; Biology; Mutant; Cholinergic neuron; Allele; Cell biology; Genetics; Neuroscience; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006879249,0.001611924,0.0007281139,0.002112517,0.0005559982,0.0006539174,0.001044638,0.001373965,0.002534786],"category_scores_gemma":[0.0004153114,0.000737157,0.0006405718,0.0004251364,0.001112325,0.000707987,0.000893739,0.002641472,0.001008681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000454348,"about_ca_system_score_gemma":0.0004002242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006257077,"about_ca_topic_score_gemma":0.001838901,"domain_scores_codex":[0.9994391,0.00008479183,0.00009928335,0.0001491991,0.0001191578,0.0001085259],"domain_scores_gemma":[0.9993398,0.0001021767,0.0002337137,0.00006596406,0.00004772811,0.0002105781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003233595,0.0002014869,0.0002638421,0.00006945544,0.0000216292,0.0003208807,0.0001206281,0.00008733817,0.9937636,0.001401189,0.0002153186,0.003211136],"study_design_scores_gemma":[0.000703875,0.002176855,0.01785482,0.0001837791,0.0002424192,0.006982549,0.000275981,0.002302382,0.9420691,0.001632322,0.02545317,0.0001227177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9247465,0.004232533,0.05840284,0.001605819,0.0003704012,0.0006105532,0.004825733,0.001327264,0.003878314],"genre_scores_gemma":[0.8478532,0.009610665,0.103729,0.001192263,0.000334508,0.001843282,0.00950567,0.001223592,0.0247077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002534786,"threshold_uncertainty_score":0.008479655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04797303246492281,"score_gpt":0.2316583082360675,"score_spread":0.1836852757711447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}