{"id":"W2061546345","doi":"10.1021/jm900178n","title":"Engineered Apoptosis-Inducing Peptides with Enhanced Mitochondrial Localization and Potency","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Peptide; Potency; Mitochondrion; Intracellular; Apoptosis; Organelle; Biochemistry; Cell culture; Cell biology; In vitro; Pharmacology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001006586,0.0001307577,0.0002762128,0.00003806786,0.00008145726,0.00001318292,0.00009040149,0.0001364765,0.00009436796],"category_scores_gemma":[0.00007902015,0.00009299132,0.00004845886,0.00006137815,0.0001170968,0.0001220279,0.000009368827,0.0003333954,0.000001859206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002651643,"about_ca_system_score_gemma":0.00006765393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007068063,"about_ca_topic_score_gemma":4.207092e-7,"domain_scores_codex":[0.9993604,0.00001803709,0.0002798742,0.0001102567,0.00006241843,0.0001689597],"domain_scores_gemma":[0.9994792,0.00004341137,0.0002496434,0.00007385397,0.0001160469,0.00003783891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000326635,0.00004458598,0.00003249203,0.00003315352,0.00005969213,0.000008994102,0.0003050525,0.00005311083,0.9931461,0.000007677863,0.001510208,0.004472254],"study_design_scores_gemma":[0.001523369,0.0004250979,0.0002130979,0.0003972735,0.0000832459,0.00083669,0.0008958575,0.000004387196,0.9947292,0.00005590847,0.0007202252,0.0001156862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888963,0.001147208,0.008296341,0.0004975832,0.0002228617,0.00004260417,0.000002167363,0.00001297708,0.0008820221],"genre_scores_gemma":[0.9982516,0.000148048,0.0005271254,0.000141454,0.0003348455,3.534709e-7,0.000007245829,0.00000700934,0.0005823647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009355318,"threshold_uncertainty_score":0.3792076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004536262901006012,"score_gpt":0.2020187194921521,"score_spread":0.1974824565911461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}