{"id":"W2061546345","doi":"10.1021/jm900178n","title":"Engineered Apoptosis-Inducing Peptides with Enhanced Mitochondrial Localization and Potency","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Peptide; Potency; Mitochondrion; Intracellular; Apoptosis; Organelle; Biochemistry; Cell culture; Cell biology; In vitro; Pharmacology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002340352,0.0003346494,0.0003544144,0.0001465743,0.00009170206,0.000446306,0.0002514182,0.0003801501,0.0005046055],"category_scores_gemma":[0.0002739551,0.0001329847,0.0002098987,0.000175979,0.0002085517,0.0003375212,0.000234591,0.0007375515,0.0002484903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002452663,"about_ca_system_score_gemma":0.0001691156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008359316,"about_ca_topic_score_gemma":0.0001475505,"domain_scores_codex":[0.9998111,0.00003914352,0.00002901995,0.00003180905,0.00004702032,0.00004189351],"domain_scores_gemma":[0.9997366,0.0000558437,0.00009813548,0.00002415293,0.00003846147,0.0000468357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006072835,0.00002555673,0.000061466,0.00003574202,0.000003597163,0.00004756374,0.000007603256,0.0002721238,0.997809,0.0001011681,0.00001526232,0.001560227],"study_design_scores_gemma":[0.00003410666,0.0005187955,0.0003737459,0.000004260331,0.00001356162,0.0003641643,0.000008015776,0.0006507567,0.9960629,0.00004126981,0.001922076,0.000006452046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859388,0.001555253,0.01073944,0.0001031685,0.00004395434,0.00009687388,0.0001708839,0.00009477357,0.001256777],"genre_scores_gemma":[0.9832169,0.0008075461,0.0145505,0.00009637297,0.0000159883,0.00004573228,0.0002288848,0.00002567512,0.001012484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005046055,"threshold_uncertainty_score":0.001779616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004536262901006012,"score_gpt":0.2020187194921521,"score_spread":0.1974824565911461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}