{"id":"W2061563398","doi":"10.1158/0008-5472.can-08-2893","title":"Repression of 15-Hydroxyprostaglandin Dehydrogenase Involves Histone Deacetylase 2 and Snail in Colorectal Cancer","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; U.S. Public Health Service; Universität Hamburg; Universitat Pompeu Fabra","keywords":"Histone deacetylase; Histone deacetylase 2; HDAC1; Cancer research; Azoxymethane; Snail; Colorectal cancer; Biology; Histone; Chemistry; Cancer; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009737626,0.0001941658,0.0001575603,0.0001529914,0.00009811933,0.0002072201,0.0001017035,0.0001298361,0.0008021665],"category_scores_gemma":[0.00007492699,0.0001349031,0.0001632322,0.0001275106,0.000226737,0.0001028388,0.0001422996,0.0002580861,0.0002190986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003152448,"about_ca_system_score_gemma":0.0002045243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006745932,"about_ca_topic_score_gemma":0.001757086,"domain_scores_codex":[0.9999295,0.00001300571,0.000006393078,0.00001573481,0.00001828837,0.00001700385],"domain_scores_gemma":[0.9999509,0.000004437946,0.00001674346,0.000004938127,0.000005740445,0.00001733622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001986951,0.00001221463,0.0008928461,0.00005543171,0.000005754875,0.00007531145,0.000009859362,0.0000644407,0.9967096,0.0001485466,0.00005213215,0.001775333],"study_design_scores_gemma":[0.0000605594,0.0005749701,0.03922917,0.00001087905,0.00002665011,0.001009832,0.00005833891,0.001315304,0.9485701,0.0001362411,0.008999751,0.000008043835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983252,0.01021076,0.002868771,0.0002789933,0.00004690168,0.00003907295,0.0003259151,0.0001216175,0.002855974],"genre_scores_gemma":[0.9943017,0.002228598,0.0009309308,0.00004600373,0.00000671091,0.00001558787,0.0002305075,0.000006006535,0.002233892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008021665,"threshold_uncertainty_score":0.002683461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0454921925363518,"score_gpt":0.3889743918214862,"score_spread":0.3434821992851345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}