{"id":"W2061582311","doi":"10.1002/jcp.21826","title":"Self‐renewal and pluripotency is maintained in human embryonic stem cells by co‐culture with human fetal liver stromal cells expressing hypoxia inducible factor 1α","year":2009,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vector Institute","keywords":"Embryonic stem cell; Stromal cell; Cell biology; Hypoxia (environmental); Stem cell; Fetus; Hypoxia-inducible factors; Biology; Cell culture; KOSR; Immunology; Cancer research; Andrology; Adult stem cell; Chemistry; Medicine; Genetics; Gene; Pregnancy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000277718,0.0003950838,0.0005913474,0.0001839396,0.0001963257,0.00006706585,0.0004737813,0.0004149587,0.0000508844],"category_scores_gemma":[0.000004216492,0.0003182892,0.000172579,0.0001366075,0.0001750985,0.00003606409,0.0001224325,0.0006313002,0.000004886243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007653179,"about_ca_system_score_gemma":0.0001418261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001477527,"about_ca_topic_score_gemma":0.000005429032,"domain_scores_codex":[0.9974765,0.0003390329,0.0005710842,0.0005670684,0.0003836132,0.0006627069],"domain_scores_gemma":[0.9986806,0.00001778022,0.000487588,0.0003751068,0.0001771899,0.0002617408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002524969,0.0003461677,0.0001332951,0.00006383482,0.000116701,0.0001452669,0.0002907749,0.00004774861,0.9970591,0.000009325055,0.001362093,0.0001732105],"study_design_scores_gemma":[0.002336634,0.003371047,0.001270275,0.00006240833,0.00003804697,0.00009562335,0.0001902869,0.0000553976,0.9901308,0.00007862506,0.002014031,0.0003567979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970545,0.002078009,0.0002098602,0.00006256151,0.00006807417,0.0002615325,0.00003478555,0.000009563551,0.0002211674],"genre_scores_gemma":[0.9977117,0.0002969337,0.0005134843,0.0001235615,0.0002884344,0.000003049945,0.0000478448,0.0000386104,0.0009764049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006928258,"threshold_uncertainty_score":0.9999269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01040612343814439,"score_gpt":0.2456072660035956,"score_spread":0.2352011425654512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}