{"id":"W2061592265","doi":"10.1016/j.biologicals.2011.09.004","title":"Evaluation of similar biotherapeutic products: Scientific and regulatory challenges","year":2011,"lang":"en","type":"editorial","venue":"Biologicals","topic":"Biotechnology and Related Fields","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"","keywords":"Biochemical engineering; Computational biology; Chemistry; Computer science; Biology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.003210573,0.0001965588,0.000498417,0.0001767826,0.00006781868,0.000005468155,0.0001290293,0.01049135,0.0001300698],"category_scores_gemma":[0.001876878,0.0001210823,0.00006399824,0.0001376486,0.001045924,0.00001760689,0.00006244595,0.001531563,0.00001300979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003332541,"about_ca_system_score_gemma":0.0003170888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001978485,"about_ca_topic_score_gemma":0.000001130647,"domain_scores_codex":[0.9982065,0.00021957,0.0003009835,0.0005797583,0.0005145267,0.0001786643],"domain_scores_gemma":[0.9982517,0.0001323781,0.0002271995,0.0005279329,0.0008177807,0.00004294719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003542362,0.0006404544,0.00005771818,0.001099711,0.001172645,0.00001049485,0.0003169277,2.013825e-7,0.03539459,0.002079031,0.8190087,0.1398653],"study_design_scores_gemma":[0.0008485266,0.0008523102,0.001389402,0.0003840255,0.001054015,0.000007427124,0.00003898205,0.000006909855,0.008360435,0.002768696,0.9840888,0.0002004649],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.02799015,0.3408205,0.000002125587,0.005735537,0.6209466,0.001366864,0.00004656176,0.0001840049,0.002907673],"genre_scores_gemma":[0.2429122,0.1992713,0.001275928,0.0002107321,0.5521476,0.0001703272,0.0006492254,0.00009990547,0.003262742],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.2149221,"threshold_uncertainty_score":0.9907932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.106109367783805,"score_gpt":0.3257099174395529,"score_spread":0.2196005496557479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}