{"id":"W2061596300","doi":"10.1016/j.yjmcc.2009.05.002","title":"Rac1 mediates sex difference in cardiac tumor necrosis factor-α expression via NADPH oxidase–ERK1/2/p38 MAPK pathway in endotoxemia","year":2009,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"NADPH oxidase; Endocrinology; Internal medicine; Tumor necrosis factor alpha; MAPK/ERK pathway; RAC1; p38 mitogen-activated protein kinases; Estrogen; Lipopolysaccharide; Knockout mouse; Apocynin; Biology; Phosphorylation; Medicine; Oxidative stress; Signal transduction; Receptor; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002491197,0.0003011786,0.0002789401,0.0002872967,0.0002639694,0.0003277561,0.0002906307,0.0003385675,0.003285754],"category_scores_gemma":[0.0004042202,0.000320646,0.0002593953,0.000119957,0.0002863865,0.000333274,0.0002385408,0.0005315976,0.0004621531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000191143,"about_ca_system_score_gemma":0.0002533742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004690252,"about_ca_topic_score_gemma":0.0005561642,"domain_scores_codex":[0.9997962,0.00004291686,0.00001230357,0.00005346656,0.00002902414,0.00006608494],"domain_scores_gemma":[0.9997417,0.00003443146,0.00007494626,0.00003698843,0.00003027442,0.00008163731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007192133,0.0003551742,0.01336893,0.00008891276,0.00004219924,0.0007796499,0.0003048332,0.00006215298,0.9698966,0.0005946266,0.000346807,0.006967891],"study_design_scores_gemma":[0.0004589302,0.00255453,0.6505355,0.00005837253,0.0002461959,0.004447741,0.0009441429,0.001694671,0.3328264,0.00102838,0.005143337,0.0000619111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975217,0.0006876374,0.0006665284,0.0001611959,0.00006851989,0.00001108142,0.0001996018,0.00001680475,0.0006668402],"genre_scores_gemma":[0.995438,0.0004988309,0.0002793537,0.00007279835,0.00003455385,0.00003689733,0.0001938235,0.00001908357,0.003426689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003285754,"threshold_uncertainty_score":0.01099199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007239338914552334,"score_gpt":0.2037435009389828,"score_spread":0.1965041620244305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}