{"id":"W2061606662","doi":"10.1074/jbc.m203201200","title":"Cyclooxygenase-2 and Presenilin-1 Gene Expression Induced by Interleukin-1β and Amyloid β42 Peptide Is Potentiated by Hypoxia in Primary Human Neural Cells","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; U.S. Public Health Service; National Institutes of Health; University of Toronto; Oregon State University; McLean Hospital","keywords":"Hypoxia (environmental); Cyclooxygenase; Presenilin; Interleukin 1β; Peptide; Chemistry; Pharmacology; Cell biology; Interleukin; Neuroscience; Internal medicine; Biology; Medicine; Alzheimer's disease; Biochemistry; Enzyme; Disease; Cytokine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001713725,0.0002827711,0.0003662022,0.00003487181,0.0000735893,0.00004362126,0.0002536335,0.0005240738,0.000107161],"category_scores_gemma":[0.00007183378,0.0002140871,0.00009799366,0.00007915597,0.0001580681,0.00001771376,0.0002185874,0.0004998113,9.778774e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004010471,"about_ca_system_score_gemma":0.00001510159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003602497,"about_ca_topic_score_gemma":2.264386e-7,"domain_scores_codex":[0.9984562,0.00009667416,0.0005451881,0.0004175454,0.0001657034,0.0003186579],"domain_scores_gemma":[0.9991438,0.00002322145,0.0003286729,0.0001801597,0.00007287707,0.000251216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001495523,0.0002061202,0.00346656,0.0000272927,0.00003961572,0.00001626166,0.00003038311,0.000001105247,0.9892883,1.611449e-8,0.006416397,0.0003584411],"study_design_scores_gemma":[0.00118675,0.0003702623,0.001358834,0.00003400546,0.00001082347,0.0001282423,0.00004878824,0.00001255033,0.9953712,0.000007548205,0.001217749,0.0002531988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959368,0.003579898,0.000005598867,0.0001293079,0.00004690445,0.0000937995,0.00005419134,0.000008793484,0.0001447184],"genre_scores_gemma":[0.9977892,0.001298719,0.0001456738,0.0002747249,0.0001509686,0.000004974902,0.00007488425,0.00002015719,0.0002407005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006082993,"threshold_uncertainty_score":0.873022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01405544324496716,"score_gpt":0.2253582401061131,"score_spread":0.2113027968611459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}