{"id":"W2061620261","doi":"10.1021/jm3017255","title":"Inhibiting Aberrant Signal Transducer and Activator of Transcription Protein Activation with Tetrapodal, Small Molecule Src Homology 2 Domain Binders: Promising Agents against Multiple Myeloma","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"STAT protein; STAT3; Chemistry; stat; Small molecule; Cancer research; Intracellular; Proto-oncogene tyrosine-protein kinase Src; Multiple myeloma; Transcription factor; Activator (genetics); In vitro; SH2 domain; Cell biology; Phosphorylation; Biochemistry; Biology; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544143,0.000407618,0.0003563917,0.0003915258,0.0001384402,0.0001973101,0.0002654198,0.0002537908,0.001146413],"category_scores_gemma":[0.00006841673,0.0001438826,0.0002714609,0.0003248237,0.0001570709,0.0002155068,0.0001874559,0.0005546025,0.0003095693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001969963,"about_ca_system_score_gemma":0.0001875158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004318951,"about_ca_topic_score_gemma":0.001835415,"domain_scores_codex":[0.9999516,0.000007720907,0.000003109973,0.000007458608,0.00001315198,0.00001703688],"domain_scores_gemma":[0.9999783,0.000003321431,0.000005942133,0.000001545894,0.000003153461,0.000007801601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001053533,0.000971284,0.0004895268,0.0004616069,0.00007304309,0.0004104536,0.00007878568,0.002111013,0.9055353,0.000893599,0.001953712,0.085968],"study_design_scores_gemma":[0.001932685,0.01545725,0.009511174,0.00006434492,0.0002436092,0.002107291,0.00006803116,0.006290088,0.9268419,0.000527857,0.03689086,0.00006487303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9371273,0.04458942,0.008434052,0.0006822346,0.0002081173,0.0004148469,0.0009723536,0.0004944013,0.007077197],"genre_scores_gemma":[0.9635708,0.02622738,0.004263896,0.0003894107,0.00006167504,0.0001438751,0.001014743,0.00001965649,0.004308491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146413,"threshold_uncertainty_score":0.003835082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02356133671486433,"score_gpt":0.2549266967580899,"score_spread":0.2313653600432256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}