{"id":"W2061631848","doi":"10.1007/s00775-009-0612-7","title":"Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation","year":2009,"lang":"en","type":"article","venue":"JBIC Journal of Biological Inorganic Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; University of Ottawa","funders":"Canadian Institutes of Health Research; Diabète Québec","keywords":"Phosphorylation; Protein kinase B; Insulin receptor; Chemistry; Cell biology; Tyrosine phosphorylation; Signal transduction; Receptor tyrosine kinase; Kinase; Tyrosine kinase; Chinese hamster ovary cell; Epidermal growth factor; Insulin-like growth factor; Growth factor; Cancer research; Receptor; Endocrinology; Biochemistry; Biology; Insulin; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001856398,0.0003443781,0.0003141413,0.0002535013,0.0002440128,0.0004646387,0.0003857257,0.0002770244,0.001843933],"category_scores_gemma":[0.0001402241,0.0002662866,0.0003425665,0.0001381469,0.0002377044,0.0005847845,0.0003240417,0.0005157999,0.0004002608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006104442,"about_ca_system_score_gemma":0.0003081529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002394386,"about_ca_topic_score_gemma":0.005475869,"domain_scores_codex":[0.9998586,0.00001492383,0.00001142864,0.0000216906,0.00002695721,0.00006638849],"domain_scores_gemma":[0.9999325,0.00001478386,0.000008458645,0.00001241688,0.00001014426,0.00002170245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004510456,0.0000261604,0.0002069147,0.00003563999,0.000004809619,0.00008886741,0.00002435452,0.00004519018,0.9976171,0.0003411194,0.00005621665,0.001102682],"study_design_scores_gemma":[0.00005763552,0.00009370312,0.01864569,0.000005632577,0.00002196478,0.0004079118,0.00009978498,0.001149077,0.976674,0.0001359527,0.002700523,0.000008104771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884056,0.002958504,0.00315469,0.0002007907,0.00006292173,0.00003235056,0.0005626165,0.00009965709,0.00452287],"genre_scores_gemma":[0.9912946,0.0007359719,0.001767804,0.00004500839,0.00001480044,0.00003284169,0.0004172763,0.00002354063,0.005668261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002394386,"threshold_uncertainty_score":0.006168544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0137897721231867,"score_gpt":0.2380454544339375,"score_spread":0.2242556823107508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}