{"id":"W2061631848","doi":"10.1007/s00775-009-0612-7","title":"Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation","year":2009,"lang":"en","type":"article","venue":"JBIC Journal of Biological Inorganic Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; University of Ottawa","funders":"Canadian Institutes of Health Research; Diabète Québec","keywords":"Phosphorylation; Protein kinase B; Insulin receptor; Chemistry; Cell biology; Tyrosine phosphorylation; Signal transduction; Receptor tyrosine kinase; Kinase; Tyrosine kinase; Chinese hamster ovary cell; Epidermal growth factor; Insulin-like growth factor; Growth factor; Cancer research; Receptor; Endocrinology; Biochemistry; Biology; Insulin; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003338862,0.0001300725,0.0002359453,0.00002894601,0.00003307634,0.00001379582,0.0001016163,0.0002565307,0.00003448787],"category_scores_gemma":[0.0001776033,0.0001043016,0.00005048401,0.0001082146,0.00006409336,0.000007486859,0.00004656435,0.0001930879,3.116411e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002046503,"about_ca_system_score_gemma":0.00005418466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001212311,"about_ca_topic_score_gemma":5.09933e-7,"domain_scores_codex":[0.9990713,0.00003949144,0.0004475219,0.0001873982,0.0001098626,0.0001444226],"domain_scores_gemma":[0.9993337,0.0000290474,0.0003337107,0.000103682,0.0001095818,0.000090248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000107865,0.00005754023,0.002886416,0.00001778332,0.000008581861,0.000007315702,0.00005320093,0.000008197373,0.9927123,0.00001211706,0.00002838072,0.004100285],"study_design_scores_gemma":[0.0007484299,0.0002898854,0.01140045,0.00004450353,0.00000784398,0.00007743396,0.0001856128,0.00002672881,0.9865466,0.0002747871,0.0002770484,0.0001207073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904634,0.009049321,0.0000831982,0.0001443748,0.00002681353,0.00005658299,0.000002302493,0.000003347648,0.0001706881],"genre_scores_gemma":[0.9980328,0.001312218,0.0003931786,0.00006467781,0.0001635349,4.732271e-7,0.00001398141,0.000005683315,0.00001341603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008514035,"threshold_uncertainty_score":0.4253295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0137897721231867,"score_gpt":0.2380454544339375,"score_spread":0.2242556823107508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}