{"id":"W2061633459","doi":"10.1016/j.imbio.2010.11.004","title":"Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS","year":2010,"lang":"en","type":"article","venue":"Immunobiology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Saskatchewan Health Research Foundation","keywords":"CD86; Cell biology; Dendritic cell; Chemokine; MHC class II; Immune system; CD80; MHC class I; Antigen presentation; T cell; Tumor necrosis factor alpha; Biology; Prostaglandin E2; C-C chemokine receptor type 7; Chemistry; Immunology; Major histocompatibility complex; CD40; Cytotoxic T cell; In vitro; Endocrinology; Chemokine receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003983325,0.0006710379,0.00116514,0.0002592088,0.0004460554,0.00006022064,0.0004178223,0.001048895,0.0004024967],"category_scores_gemma":[0.0001354716,0.0004795398,0.00009623525,0.0002753604,0.001546689,0.0001509621,0.0001458061,0.00115325,0.00002096615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004046128,"about_ca_system_score_gemma":0.0002038106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006750554,"about_ca_topic_score_gemma":0.0004125108,"domain_scores_codex":[0.9968752,0.0006099511,0.0006756883,0.0008381556,0.00006640277,0.0009345601],"domain_scores_gemma":[0.9978466,0.0006441136,0.0004798453,0.0007568047,0.0002119439,0.00006068173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008034651,0.0002262166,0.005688107,0.0001278263,0.0006259803,0.00005873378,0.001729915,5.192485e-7,0.9816335,0.00005085326,0.0005028603,0.001320802],"study_design_scores_gemma":[0.006599722,0.002168011,0.05498949,0.0002705443,0.0001982012,0.001358026,0.001843099,0.000001436404,0.9260855,0.00002341257,0.005810746,0.0006517834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986865,0.009197307,0.000009189308,0.0005172717,0.0007106217,0.001016381,0.00156221,0.00009598905,0.00002604817],"genre_scores_gemma":[0.993907,0.0004723295,0.0002123861,0.0002287725,0.00003228231,0.00009927738,0.0003343908,0.0000857432,0.004627842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05554801,"threshold_uncertainty_score":0.9997656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00815772985972965,"score_gpt":0.2196150392364714,"score_spread":0.2114573093767418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}