{"id":"W2061633459","doi":"10.1016/j.imbio.2010.11.004","title":"Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS","year":2010,"lang":"en","type":"article","venue":"Immunobiology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Saskatchewan Health Research Foundation","keywords":"CD86; Cell biology; Dendritic cell; Chemokine; MHC class II; Immune system; CD80; MHC class I; Antigen presentation; T cell; Tumor necrosis factor alpha; Biology; Prostaglandin E2; C-C chemokine receptor type 7; Chemistry; Immunology; Major histocompatibility complex; CD40; Cytotoxic T cell; In vitro; Endocrinology; Chemokine receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004116493,0.0008686276,0.001206715,0.0005592358,0.000275737,0.0006766949,0.0002121152,0.0006241924,0.001919457],"category_scores_gemma":[0.0003358485,0.0003134066,0.0004664024,0.0005074777,0.0003021176,0.0004406426,0.0004290864,0.001646442,0.0009476037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002174337,"about_ca_system_score_gemma":0.0002600895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001427477,"about_ca_topic_score_gemma":0.0002483669,"domain_scores_codex":[0.9995102,0.00008749273,0.00005766994,0.00007222044,0.0001294049,0.0001430033],"domain_scores_gemma":[0.9994947,0.0001350251,0.00009451966,0.00008091236,0.0000543901,0.000140504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00047552,0.00005775431,0.0001360499,0.00003327163,0.000006281663,0.00006614318,0.000008527174,0.00003922922,0.9981983,0.00002702897,0.00003551258,0.0009164673],"study_design_scores_gemma":[0.00005937048,0.000476888,0.001830678,0.000004135301,0.00002267301,0.000189515,0.0000146743,0.0002268003,0.9956179,0.0000432941,0.001507823,0.000006426876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864444,0.001737445,0.006073095,0.0002048858,0.0004134303,0.0001546911,0.001177758,0.0001724057,0.00362191],"genre_scores_gemma":[0.9850795,0.001254136,0.006851658,0.000172408,0.0002239183,0.000172537,0.002201339,0.00008197947,0.003962628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001919457,"threshold_uncertainty_score":0.006421208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00815772985972965,"score_gpt":0.2196150392364714,"score_spread":0.2114573093767418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}