{"id":"W2061636592","doi":"10.1042/bj20050411","title":"Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction","year":2005,"lang":"en","type":"review","venue":"Biochemical Journal","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":410,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Cancer Institute; Cancer Research Society","keywords":"Protein–protein interaction; Biology; SH3 domain; Computational biology; Signal transduction; SH2 domain; Proto-oncogene tyrosine-protein kinase Src; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433279,0.0002021283,0.000192777,0.0001444589,0.0001245141,0.0003517953,0.0002733566,0.0002541981,0.0005324993],"category_scores_gemma":[0.00009843815,0.00009026352,0.0001459064,0.0001841674,0.0004961696,0.000288828,0.0002102693,0.0003441026,0.0002488877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002175021,"about_ca_system_score_gemma":0.00009998235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003385241,"about_ca_topic_score_gemma":0.0002566396,"domain_scores_codex":[0.9999249,0.000009254934,0.000003831506,0.00002138739,0.00001922206,0.00002144396],"domain_scores_gemma":[0.9999398,0.00001146943,0.00002126817,0.000005245743,0.000006837642,0.00001549875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000148403,0.00001689906,0.001285169,0.00008774117,0.000008915353,0.000290442,0.00003413542,0.0005167912,0.9887649,0.001953924,0.00007864272,0.006814065],"study_design_scores_gemma":[0.00007906057,0.000507397,0.1076199,0.00002735196,0.00006908286,0.005787225,0.0002304684,0.01059047,0.8434147,0.01228193,0.01931989,0.00007255498],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9682805,0.0192732,0.006572894,0.0004143318,0.00003263634,0.00001113321,0.0001479284,0.00006096195,0.005206355],"genre_scores_gemma":[0.995391,0.003150978,0.0007150126,0.00005995322,0.00002277454,0.00000499059,0.00006813191,0.000005750152,0.0005814416],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0005324993,"threshold_uncertainty_score":0.001781404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03917559966248316,"score_gpt":0.3074130146583277,"score_spread":0.2682374149958445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}