{"id":"W2061640456","doi":"10.1074/jbc.m605095200","title":"Cathepsin D, a Lysosomal Protease, Regulates ABCA1-mediated Lipid Efflux","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"ABCA1; Cathepsin D; Biology; Endosome; Cholesterol; Molecular biology; Cell biology; Biochemistry; Intracellular; Gene; Transporter; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003060008,0.0001975927,0.0005461007,0.00003881567,0.00004162835,0.00002115761,0.0001563081,0.0003008794,0.0003669891],"category_scores_gemma":[0.0003861969,0.0001177181,0.0002968875,0.000156407,0.0001531371,0.00004936452,0.0000403652,0.0004908732,0.00002206442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005335205,"about_ca_system_score_gemma":0.00009993728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007708597,"about_ca_topic_score_gemma":1.842129e-7,"domain_scores_codex":[0.9985794,0.00003660126,0.0006356788,0.0001893935,0.0002775975,0.0002812964],"domain_scores_gemma":[0.9989015,0.00009423417,0.0003780217,0.0001854658,0.0002009581,0.0002397735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004227054,0.0004478476,0.02636365,0.00007051136,0.00004617869,0.0001197777,0.00001485667,0.000002857308,0.9684125,0.00000580867,0.00320284,0.0008904235],"study_design_scores_gemma":[0.0038298,0.0003904382,0.2370155,0.0002215848,0.0001260809,0.002528725,0.00004738561,0.00002300726,0.6732249,0.000267204,0.08208753,0.0002378566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955128,0.0009420714,0.00001253696,0.00136039,0.0001429233,0.0001211252,0.00001031609,0.00003579927,0.00186198],"genre_scores_gemma":[0.9938498,0.00007031205,0.0006192539,0.0003460999,0.003736665,0.000004739274,0.00003270499,0.00001297428,0.001327503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2951876,"threshold_uncertainty_score":0.4800404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479164668719824,"score_gpt":0.2404626405295548,"score_spread":0.2256709938423566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}