{"id":"W2061641303","doi":"10.3390/ijms15045508","title":"Transgene IL-6 Enhances DC-Stimulated CTL Responses by Counteracting CD4+25+Foxp3+ Regulatory T Cell Suppression via IL-6-Induced Foxp3 Downregulation","year":2014,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Saskatchewan Health Research Foundation; Cure Brain Cancer Foundation; Saskatchewan Cancer Agency","keywords":"CTL*; FOXP3; Cytotoxic T cell; Biology; Immune system; Immunology; Transgene; Immunotherapy; Cancer research; Immune tolerance; T cell; CD8; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283976,0.0004507345,0.0002537663,0.0002269085,0.00007300435,0.0002458095,0.0001781574,0.0002223231,0.001316574],"category_scores_gemma":[0.00007871888,0.0001197091,0.0002656742,0.0001076393,0.000216922,0.0001783218,0.0001496118,0.001073067,0.0003553709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001460765,"about_ca_system_score_gemma":0.0001876612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001948899,"about_ca_topic_score_gemma":0.0003074677,"domain_scores_codex":[0.9997992,0.00002875864,0.00002419288,0.00003863029,0.00005947353,0.00004981085],"domain_scores_gemma":[0.9998957,0.00001134251,0.00003643135,0.000009897266,0.00001039622,0.00003619213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008496505,0.0000496168,0.0000954348,0.00003517241,0.00000255559,0.00001789997,0.000007562329,0.00006819273,0.9986395,0.00003822406,0.00001748302,0.0009433635],"study_design_scores_gemma":[0.00004294108,0.000569638,0.001314101,0.000006330034,0.00001905559,0.0001251452,0.00001302301,0.001181299,0.9952881,0.00003703977,0.001400479,0.000002720002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909305,0.001446347,0.005388664,0.0001501568,0.00007219595,0.00005222797,0.000263647,0.0002160664,0.001480305],"genre_scores_gemma":[0.9927968,0.0008119273,0.00343358,0.00006121531,0.00003019076,0.00004311918,0.000332293,0.00002234925,0.002468397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316574,"threshold_uncertainty_score":0.004404366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01051451747339067,"score_gpt":0.2750905250999922,"score_spread":0.2645760076266015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}