{"id":"W2061661303","doi":"10.1074/jbc.m703800200","title":"Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; Office of Science; Basic Energy Sciences; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Wellcome Trust; National Institutes of Health; Ontario Genomics; March of Dimes Foundation; Genome Canada; Ontario Innovation Trust; Ontario Genomics Institute; American Heart Association; Argonne National Laboratory; U.S. Department of Energy","keywords":"GTPase; CDC42; Cell biology; GTPase-activating protein; Plasma protein binding; Allosteric regulation; Binding domain; Biology; Chemistry; Signal transduction; Binding site; Receptor; Biochemistry; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005310732,0.0001017808,0.0002266559,0.00003469802,0.00005903356,0.0000104872,0.0001896003,0.00008389745,0.00003682828],"category_scores_gemma":[0.001842533,0.0000596176,0.0001046163,0.0002350361,0.0001409599,0.00007239578,0.00007864574,0.0002187236,6.542298e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003366267,"about_ca_system_score_gemma":0.00002142574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001699751,"about_ca_topic_score_gemma":2.581252e-7,"domain_scores_codex":[0.9989451,0.00005850728,0.0004893859,0.0001532158,0.0002103087,0.0001435201],"domain_scores_gemma":[0.9984443,0.0007546252,0.0005611784,0.00009050585,0.00006351229,0.00008589275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003549815,0.0001137709,0.005040207,0.00004026392,0.000004319026,0.000005632272,0.00006738143,0.00004510852,0.993811,0.00001427182,0.000005150126,0.0004979033],"study_design_scores_gemma":[0.0003875653,0.0002294604,0.006552397,0.0001362543,0.000008611771,0.000106859,0.0001032372,0.00002576427,0.9922473,0.00005402233,0.00008692336,0.00006160809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971583,0.0000370356,0.002409653,0.0001111717,0.0001057817,0.00008377768,0.000009349703,0.00000488605,0.00008004206],"genre_scores_gemma":[0.9992843,0.00002438891,0.0004880058,0.0001010565,0.00008584708,8.276609e-7,4.157299e-7,0.000005168751,0.00000998788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002125999,"threshold_uncertainty_score":0.2431135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0472387115392421,"score_gpt":0.2981302283334677,"score_spread":0.2508915167942256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}