{"id":"W2061661303","doi":"10.1074/jbc.m703800200","title":"Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; Office of Science; Basic Energy Sciences; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Wellcome Trust; National Institutes of Health; Ontario Genomics; March of Dimes Foundation; Genome Canada; Ontario Innovation Trust; Ontario Genomics Institute; American Heart Association; Argonne National Laboratory; U.S. Department of Energy","keywords":"GTPase; CDC42; Cell biology; GTPase-activating protein; Plasma protein binding; Allosteric regulation; Binding domain; Biology; Chemistry; Signal transduction; Binding site; Receptor; Biochemistry; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128946,0.00028442,0.0001944878,0.00008476884,0.0002334862,0.0001975294,0.0002999447,0.0002330814,0.00135783],"category_scores_gemma":[0.000131479,0.0001283494,0.0002120224,0.00005359641,0.0001584423,0.0001084518,0.0002169683,0.0004571849,0.0003282139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002932545,"about_ca_system_score_gemma":0.000183178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005541159,"about_ca_topic_score_gemma":0.0007145175,"domain_scores_codex":[0.9998817,0.00002754616,0.000007049858,0.00002308695,0.00003111522,0.00002947841],"domain_scores_gemma":[0.9999241,0.00001262378,0.00001926094,0.00000732076,0.000006864585,0.00002979446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001392943,0.00004989822,0.0002761454,0.00002686299,0.0000100226,0.0001208012,0.00001945394,0.0001354056,0.9981202,0.0001415996,0.0001003698,0.0008598177],"study_design_scores_gemma":[0.00004375253,0.0001562036,0.01020166,0.00001243177,0.0000206372,0.0007356321,0.00005462613,0.003995731,0.9809524,0.0001162813,0.003698344,0.00001230586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981315,0.0004051998,0.0005851173,0.00007156673,0.00001219853,0.000005633005,0.00006220554,0.00002972131,0.0006969425],"genre_scores_gemma":[0.997945,0.0001669733,0.0004851985,0.00007402473,0.00000425835,0.000009894306,0.0002565586,0.00001014793,0.001047991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135783,"threshold_uncertainty_score":0.004542351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0472387115392421,"score_gpt":0.2981302283334677,"score_spread":0.2508915167942256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}