{"id":"W2061684178","doi":"10.1371/journal.pone.0010414","title":"New Vaccine Design Based on Defective Genomes That Combines Features of Attenuated and Inactivated Vaccines","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Animal Disease Management and Epidemiology","field":"Agricultural and Biological Sciences","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Commission; Instituto de Salud Carlos III; Canadian Institute of Steel Construction","keywords":"Virology; Virus; Immunogenicity; Biology; Foot-and-mouth disease virus; Vaccination; Inactivated vaccine; Infectious dose; Immune system; DNA vaccination; Outbreak; Immunization; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003294623,0.0007411216,0.0003489459,0.0003378354,0.000110814,0.0004236111,0.0006924364,0.0006572595,0.0008386317],"category_scores_gemma":[0.000288558,0.0002309273,0.0003894423,0.0001441345,0.000503504,0.0004999245,0.0002717905,0.0008383208,0.0003738728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004360938,"about_ca_system_score_gemma":0.0003523785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002137314,"about_ca_topic_score_gemma":0.0001837467,"domain_scores_codex":[0.9998108,0.00002943738,0.00001684054,0.00004582113,0.00006217208,0.00003494396],"domain_scores_gemma":[0.9998423,0.00002214403,0.00005219516,0.00002069337,0.00003540016,0.00002721111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001379863,0.0001230049,0.000291919,0.0001354299,0.00001468782,0.0000520498,0.00001584498,0.001854837,0.9906356,0.001539374,0.0001108904,0.005088492],"study_design_scores_gemma":[0.0001595164,0.003682158,0.0008781211,0.00003597938,0.0001282755,0.0006635939,0.00001993982,0.01030698,0.9679368,0.0008729144,0.01529449,0.00002131598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8605138,0.003217272,0.130721,0.0003941327,0.0002465273,0.0004288157,0.0004206663,0.0004296354,0.003628062],"genre_scores_gemma":[0.9020029,0.001966524,0.09147839,0.000272902,0.00005381637,0.0002764778,0.00120295,0.00007219965,0.002673837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008386317,"threshold_uncertainty_score":0.003164113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05696230524887338,"score_gpt":0.2219805196595972,"score_spread":0.1650182144107238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}