{"id":"W2061702605","doi":"10.1016/j.cmet.2013.03.003","title":"Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver","year":2013,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; Biology; Mechanistic target of rapamycin; RPTOR; Lipid metabolism; Sirolimus; Cell biology; Sterol regulatory element-binding protein; Gene; Transcription factor; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002033639,0.0005169121,0.000248632,0.0004470096,0.0001885503,0.0003404938,0.0002055981,0.0002102035,0.002406723],"category_scores_gemma":[0.0001957844,0.0002868683,0.0002580482,0.0001658809,0.000341378,0.000249076,0.0002847299,0.0006101284,0.0004065682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003116683,"about_ca_system_score_gemma":0.0001855183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002974164,"about_ca_topic_score_gemma":0.0006071175,"domain_scores_codex":[0.9998049,0.00004814752,0.00001564809,0.0000364907,0.00004071239,0.00005407515],"domain_scores_gemma":[0.9998482,0.00001748639,0.00005996483,0.00001870364,0.00001491962,0.00004068369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000582792,0.00005104477,0.001850842,0.00002854731,0.00001822041,0.0002852076,0.000009805372,0.0002041762,0.9935638,0.0007620024,0.00009677104,0.002546767],"study_design_scores_gemma":[0.00007151759,0.0005172823,0.09512535,0.00001510796,0.00009232998,0.002480199,0.0001863819,0.002610724,0.8951004,0.0009323618,0.002848167,0.00002022575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917806,0.002177205,0.003025363,0.0004806211,0.0000467215,0.00002088407,0.0004055324,0.0001475113,0.001915611],"genre_scores_gemma":[0.9971782,0.0006387699,0.0008726799,0.00005304312,0.00001374013,0.00001390382,0.0002186405,0.00001644676,0.0009944993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002406723,"threshold_uncertainty_score":0.008051276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01445181765485336,"score_gpt":0.2449398968958366,"score_spread":0.2304880792409833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}