{"id":"W2061709697","doi":"10.1097/brs.0b013e318053ec35","title":"Brain-Derived Neurotrophic Factor Gene Transfer With Adeno-Associated Viral and Lentiviral Vectors Prevents Rubrospinal Neuronal Atrophy and Stimulates Regeneration-Associated Gene Expression After Acute Cervical Spinal Cord Injury","year":2007,"lang":"en","type":"article","venue":"Spine","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; University of British Columbia; Université de Montréal; International Collaboration On Repair Discoveries","funders":"National Institute of Neurological Disorders and Stroke; National Eye Institute","keywords":"Medicine; Neurotrophic factors; Regeneration (biology); Adeno-associated virus; Spinal cord; Atrophy; Viral vector; Brain-derived neurotrophic factor; Gene transfer; Genetic enhancement; Spinal cord injury; Neuroscience; Virology; Vector (molecular biology); Pathology; Gene; Cell biology; Internal medicine; Biology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004124046,0.001038492,0.0007869378,0.0007339595,0.0003024286,0.0004357186,0.0008630291,0.0008060487,0.002324926],"category_scores_gemma":[0.0002828975,0.0002592729,0.0006397113,0.0002255131,0.001086827,0.0005233687,0.0003430141,0.001092908,0.0005913405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008062054,"about_ca_system_score_gemma":0.001128001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002073571,"about_ca_topic_score_gemma":0.003008521,"domain_scores_codex":[0.9994654,0.00004230735,0.00006879838,0.0001127838,0.0001532226,0.0001575269],"domain_scores_gemma":[0.9995629,0.0000464511,0.0001584802,0.00005211324,0.00003714395,0.0001427913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000647979,0.0006453248,0.0001817645,0.0002110958,0.0000178457,0.0001131263,0.00003644006,0.00007784184,0.9949358,0.0001245118,0.00005973859,0.002948747],"study_design_scores_gemma":[0.0005494342,0.008106122,0.004076383,0.00007704231,0.0001095132,0.0004405988,0.00006581362,0.0009090074,0.9836718,0.00006364485,0.001913644,0.00001702545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931565,0.001777362,0.003164987,0.00009272644,0.00006041695,0.0003654407,0.0002333854,0.0001961131,0.000953105],"genre_scores_gemma":[0.9802465,0.002853526,0.008793399,0.0001058249,0.00005558748,0.001021505,0.001075655,0.00007761904,0.005770309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002324926,"threshold_uncertainty_score":0.007777691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586853097838348,"score_gpt":0.2690320779627762,"score_spread":0.2531635469843927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}