{"id":"W2061709697","doi":"10.1097/brs.0b013e318053ec35","title":"Brain-Derived Neurotrophic Factor Gene Transfer With Adeno-Associated Viral and Lentiviral Vectors Prevents Rubrospinal Neuronal Atrophy and Stimulates Regeneration-Associated Gene Expression After Acute Cervical Spinal Cord Injury","year":2007,"lang":"en","type":"article","venue":"Spine","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; University of British Columbia; Université de Montréal; International Collaboration On Repair Discoveries","funders":"National Institute of Neurological Disorders and Stroke; National Eye Institute","keywords":"Medicine; Neurotrophic factors; Regeneration (biology); Adeno-associated virus; Spinal cord; Atrophy; Viral vector; Brain-derived neurotrophic factor; Gene transfer; Genetic enhancement; Spinal cord injury; Neuroscience; Virology; Vector (molecular biology); Pathology; Gene; Cell biology; Internal medicine; Biology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001811601,0.0004992798,0.0004247829,0.0001855539,0.0004757682,0.000172424,0.0001861697,0.0002494583,0.00005815658],"category_scores_gemma":[0.00009887957,0.0004110394,0.0001074225,0.0003598438,0.0003212568,0.0005395672,0.0001093011,0.0004496196,0.000005003922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008118273,"about_ca_system_score_gemma":0.00006261378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001471893,"about_ca_topic_score_gemma":0.00002833717,"domain_scores_codex":[0.9968891,0.0003255381,0.0005430583,0.0009627026,0.0006190661,0.0006605822],"domain_scores_gemma":[0.9991624,0.00005003529,0.0001663228,0.0002505347,0.00009315662,0.0002774926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003927426,0.000254032,0.005186358,0.0000185775,0.00004620768,0.0001336444,0.00005912167,0.0000298737,0.9892926,0.00002867286,0.00002096056,0.001002537],"study_design_scores_gemma":[0.001743996,0.004964059,0.3008562,0.00006050921,0.00007605526,0.00003522318,0.00000165124,0.0003596733,0.6914837,0.00003828932,0.00001862844,0.0003619321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99572,0.0001396745,0.002401426,0.0003971806,0.0003729914,0.0006336698,0.000196347,0.0001309748,0.000007769658],"genre_scores_gemma":[0.9978455,0.00007819053,0.0003823733,0.000931846,0.000270405,0.00003501128,0.0000903352,0.00007401035,0.0002923419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2978088,"threshold_uncertainty_score":0.9998341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586853097838348,"score_gpt":0.2690320779627762,"score_spread":0.2531635469843927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}