{"id":"W2061721622","doi":"10.1016/s0014-5793(00)02300-0","title":"Epigenes: design and construction of new hereditary units","year":2000,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Petroleum Technology Research Centre","keywords":"Lac repressor; Plasmid; Genetics; Inheritance (genetic algorithm); Gene; Encoding (memory); Recombinant DNA; lac operon; Biology; Physics; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007481573,0.00007122654,0.00007094168,0.00002213005,0.00002842499,0.000006573131,0.00004562462,0.0000625206,0.0000537662],"category_scores_gemma":[0.00001499356,0.00007241941,0.00001870471,0.00006338421,0.00006020425,0.000002562346,0.00001086838,0.000028731,0.00000315996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003048027,"about_ca_system_score_gemma":0.00003089577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005179843,"about_ca_topic_score_gemma":0.000002875052,"domain_scores_codex":[0.9995467,0.00004235261,0.0001166097,0.0001442908,0.00005850146,0.00009154939],"domain_scores_gemma":[0.9997588,0.000009618449,0.00003552419,0.0001242846,0.00002328705,0.00004851475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005360809,0.000006742628,0.001908272,0.000008088417,0.0000234362,0.000001642839,0.00006102204,0.0009153546,0.9312332,0.00001303641,0.001937712,0.06383789],"study_design_scores_gemma":[0.0004146482,0.0001631116,0.00505403,0.00001106085,0.00001781475,0.000009214346,0.00002270813,0.00008224885,0.974974,0.0002495739,0.01886536,0.0001362631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790987,0.001417782,0.01864712,0.0003714059,0.00008036751,0.00008708728,0.000004844887,0.000005037372,0.0002876679],"genre_scores_gemma":[0.9751132,0.0009107961,0.02272245,0.0005086644,0.0003112584,0.000003359102,0.00007133131,0.00001609295,0.0003429048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06370163,"threshold_uncertainty_score":0.2953178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01651891606529515,"score_gpt":0.2253650155399697,"score_spread":0.2088460994746745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}