{"id":"W2061721622","doi":"10.1016/s0014-5793(00)02300-0","title":"Epigenes: design and construction of new hereditary units","year":2000,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Petroleum Technology Research Centre","keywords":"Lac repressor; Plasmid; Genetics; Inheritance (genetic algorithm); Gene; Encoding (memory); Recombinant DNA; lac operon; Biology; Physics; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002663659,0.0003562226,0.000209121,0.0004289326,0.0001932303,0.0003917782,0.0005334991,0.0002200509,0.001113468],"category_scores_gemma":[0.0004190707,0.0002284479,0.0002750081,0.0002786068,0.0004022598,0.0003607119,0.00054761,0.000523603,0.000443285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004652459,"about_ca_system_score_gemma":0.0003626122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002963727,"about_ca_topic_score_gemma":0.0003095247,"domain_scores_codex":[0.9998389,0.00002429696,0.00001633092,0.0000504595,0.00004292779,0.00002702345],"domain_scores_gemma":[0.9997692,0.00003711903,0.00005840745,0.00004538382,0.0000221027,0.00006794264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001357643,0.00007307497,0.00117694,0.0001647812,0.00002232043,0.0001941891,0.00009506229,0.002234221,0.9572934,0.01510442,0.0003272528,0.02317853],"study_design_scores_gemma":[0.00003840106,0.0004624696,0.001579673,0.00001363691,0.00003488709,0.0003048714,0.00002915198,0.00727994,0.9725069,0.001074128,0.016655,0.00002096592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.823837,0.0009559906,0.1686661,0.0002236512,0.0001389981,0.000294145,0.0006669722,0.001510692,0.003706441],"genre_scores_gemma":[0.8491664,0.0009687074,0.1397561,0.00006895513,0.00004157866,0.0003309954,0.001556626,0.0001999815,0.007910727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113468,"threshold_uncertainty_score":0.003724933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01651891606529515,"score_gpt":0.2253650155399697,"score_spread":0.2088460994746745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}