{"id":"W2061764868","doi":"10.1021/ed080p1439","title":"Microscale Synthesis and Spectroscopic Analysis of Flutamide, an Antiandrogen Prostate Cancer Drug","year":2003,"lang":"en","type":"article","venue":"Journal of Chemical Education","topic":"Various Chemistry Research Topics","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Flutamide; Chemistry; Antiandrogen; Combinatorial chemistry; Trifluoromethyl; Nucleophilic aromatic substitution; Phosphonium; Reactivity (psychology); Prostate cancer; Organic chemistry; Nucleophilic substitution; Androgen; Cancer; Alkyl; Hormone; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002335906,0.0001159758,0.0003690292,0.0001198246,0.00002799464,0.00003658709,0.0001703921,0.00008608407,0.0007077226],"category_scores_gemma":[0.00045442,0.0001053293,0.0001285982,0.0003304176,0.00009478235,0.0001481307,0.00001698602,0.0002457658,5.429513e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001511509,"about_ca_system_score_gemma":0.0006128374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005092211,"about_ca_topic_score_gemma":0.000004975617,"domain_scores_codex":[0.9988633,0.00002833633,0.00046338,0.0001643772,0.0002959459,0.0001846439],"domain_scores_gemma":[0.9987913,0.00008728974,0.0004048321,0.0002104116,0.0002948344,0.0002113449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003086261,0.0002840047,0.06597628,0.0001547399,0.0003364897,0.00000138293,0.0003535475,0.000006824068,0.9304207,0.00002167917,0.0002181839,0.002195329],"study_design_scores_gemma":[0.000181,0.000008348372,0.001328507,0.00007757303,0.000566715,0.00001991148,0.0002884812,0.00005808074,0.9964446,0.0002786916,0.0006517573,0.00009629508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997306,0.00122179,0.000005077452,0.0002602261,0.00004430406,0.00002961715,0.00001562446,0.000004986871,0.001112305],"genre_scores_gemma":[0.9979547,0.0003152216,0.001016613,0.00002232478,0.0001074753,0.000006773909,0.000008311818,0.00001274807,0.0005558747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06602396,"threshold_uncertainty_score":0.7749066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008206808674703603,"score_gpt":0.3026147460643448,"score_spread":0.2944079373896412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}