{"id":"W2061791452","doi":"10.1053/gast.2000.20231","title":"Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk","year":2000,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":285,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Crohn's disease; Asymptomatic; Intestinal permeability; Disease; Medicine; Family history; Inflammatory bowel disease; Gastroenterology; First-degree relatives; Internal medicine; Pathogenesis; Cohort; Risk factor; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002881199,0.0001719545,0.0001666955,0.00003718853,0.00005326504,0.000007358415,0.0002618004,0.00005684106,0.0001383868],"category_scores_gemma":[0.0001771328,0.0001232321,0.00008746742,0.0000515824,0.0004939596,0.0000043939,0.00006435327,0.0001456822,0.000006623473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001752217,"about_ca_system_score_gemma":0.0001168508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002894419,"about_ca_topic_score_gemma":0.002680703,"domain_scores_codex":[0.998388,0.0005671186,0.0002545596,0.0003500627,0.0001069314,0.000333358],"domain_scores_gemma":[0.9991927,0.00002592428,0.00009414766,0.0005086021,0.00005641006,0.0001222633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02265844,0.0002344672,0.9750199,0.00002073939,0.00003276982,0.0001528841,0.00005315798,0.0004997481,0.0009432036,0.000001856097,0.0000969787,0.0002858353],"study_design_scores_gemma":[0.001456337,0.0005958218,0.9971802,0.0000146308,0.00004336446,0.00003270818,0.00002916807,0.0002030677,0.0002538978,0.0000396396,0.00007641644,0.00007474941],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992343,0.00002046941,0.00006084502,0.00007565699,0.00002465214,0.0003257012,0.000154953,0.00001003666,0.00009344268],"genre_scores_gemma":[0.9993603,0.00002027899,0.0001418574,0.0002259003,0.00005419802,0.00007449585,0.00007416832,0.00001540275,0.00003336355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02216028,"threshold_uncertainty_score":0.5025259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004237999441533854,"score_gpt":0.2091730796665933,"score_spread":0.2049350802250595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}