{"id":"W2061846271","doi":"10.1182/blood-2010-11-321208","title":"Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":597,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Ontario Institute for Cancer Research; University of Toronto; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics; Terry Fox Foundation; GlaxoSmithKline; Ontario Innovation Trust; Deutsche Forschungsgemeinschaft; Ontario Genomics Institute; BC Cancer Foundation; Wellcome Trust; Leukemia and Lymphoma Society; Genome Canada; Pfizer","keywords":"EZH2; Biology; Histone H3; Histone methyltransferase; Molecular biology; PRC2; Methyltransferase; Histone; Methylation; Histone methylation; Mutation; Cancer research; DNA methylation; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000182593,0.0005597272,0.0002392394,0.0001854003,0.0001563287,0.0002711375,0.0002618566,0.0003096434,0.001051257],"category_scores_gemma":[0.0001687301,0.0002075892,0.0002746473,0.0001343773,0.0002951974,0.0001440873,0.0002153478,0.0004276712,0.0003050059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003964639,"about_ca_system_score_gemma":0.0002249476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005402538,"about_ca_topic_score_gemma":0.001165908,"domain_scores_codex":[0.9998428,0.00002745265,0.00001838102,0.00003473532,0.00005516276,0.00002151565],"domain_scores_gemma":[0.9999213,0.00001617489,0.0000303924,0.00001096507,0.000006012569,0.00001514653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004654374,0.000009532626,0.0003649266,0.00001391763,0.000009644367,0.00009790842,0.000005420675,0.000136412,0.9984903,0.00008439083,0.00002881084,0.0007122232],"study_design_scores_gemma":[0.00002195463,0.00008358566,0.001578729,0.000001227263,0.00001264433,0.0004190618,0.000004785123,0.0008293381,0.9963421,0.0000356141,0.0006679973,0.000002973101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930453,0.000557196,0.004724709,0.0001367264,0.00003106778,0.00003336654,0.0002442037,0.0001702782,0.001057198],"genre_scores_gemma":[0.9966249,0.0001958625,0.001959941,0.00003491742,0.000005264015,0.00001761027,0.00009654028,0.00001953716,0.001045527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001051257,"threshold_uncertainty_score":0.003516793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067644703807115,"score_gpt":0.2680245912378236,"score_spread":0.2573481441997524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}