{"id":"W2061846271","doi":"10.1182/blood-2010-11-321208","title":"Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":597,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Ontario Institute for Cancer Research; University of Toronto; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics; Terry Fox Foundation; GlaxoSmithKline; Ontario Innovation Trust; Deutsche Forschungsgemeinschaft; Ontario Genomics Institute; BC Cancer Foundation; Wellcome Trust; Leukemia and Lymphoma Society; Genome Canada; Pfizer","keywords":"EZH2; Biology; Histone H3; Histone methyltransferase; Molecular biology; PRC2; Methyltransferase; Histone; Methylation; Histone methylation; Mutation; Cancer research; DNA methylation; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000260301,0.0001823184,0.0002157147,0.00008118915,0.0001179996,0.00002015935,0.0001571231,0.000189708,0.00001990948],"category_scores_gemma":[0.000365074,0.0001828813,0.0001030007,0.0001786307,0.00004372172,0.00001257987,0.0001243506,0.00011044,0.00001875707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001610283,"about_ca_system_score_gemma":0.000141825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002136482,"about_ca_topic_score_gemma":0.0003708645,"domain_scores_codex":[0.998853,0.00009034283,0.0002732449,0.0003704536,0.0001859973,0.000226984],"domain_scores_gemma":[0.9990786,0.00006234776,0.0002015674,0.0004044948,0.0001460928,0.0001069265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006803522,0.0003530628,0.001289228,0.00002743507,0.00007680139,0.000001076891,0.0002704371,0.00002402918,0.9967928,0.0001328537,0.00001002894,0.0009542438],"study_design_scores_gemma":[0.0013068,0.0004004347,0.01130557,0.00001043396,0.000110543,0.000008094758,0.00001725255,0.0001221407,0.984229,0.002005135,0.0002823789,0.0002022286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912415,0.00009340444,0.00702305,0.00006510516,0.0001355327,0.0005220332,0.00005087438,0.0000158126,0.0008527254],"genre_scores_gemma":[0.9943562,0.00002706065,0.00503028,0.00002220834,0.0001458899,0.00005504809,0.0001349543,0.00003228534,0.0001961058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01256378,"threshold_uncertainty_score":0.7457683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067644703807115,"score_gpt":0.2680245912378236,"score_spread":0.2573481441997524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}