{"id":"W2061884616","doi":"10.1158/1538-7445.am10-1035","title":"Abstract 1035: Bcl2 is regulated by PKC and Akt and is associated with resistance to cisplatin in endometrial cancer cells.","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; Innovation and Economic Development Trois Rivières","funders":"","keywords":"Cisplatin; XIAP; Protein kinase B; Downregulation and upregulation; Cancer research; Apoptosis; MAPK/ERK pathway; Chemistry; Cell culture; Endometrial cancer; Kinase; Cancer; Biology; Medicine; Programmed cell death; Caspase; Internal medicine; Cell biology; Chemotherapy; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001251661,0.0002978593,0.0002545699,0.0003330136,0.0002207831,0.0002763304,0.0001694867,0.0003072096,0.002945786],"category_scores_gemma":[0.000124653,0.0001685894,0.000302402,0.0004819857,0.0001426882,0.0002048098,0.0001696625,0.0005735434,0.0006861211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605635,"about_ca_system_score_gemma":0.0001615375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004975674,"about_ca_topic_score_gemma":0.0004202895,"domain_scores_codex":[0.9998447,0.00001960862,0.00001991124,0.00002895297,0.00005506531,0.00003176049],"domain_scores_gemma":[0.9999157,0.000008742332,0.00002547557,0.00001158577,0.00001779937,0.00002065998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003724792,0.00004736957,0.001590197,0.00008526125,0.00001335762,0.0001901825,0.00001412475,0.00002284118,0.9955787,0.00006042746,0.0001497559,0.001875262],"study_design_scores_gemma":[0.0001073809,0.0006655673,0.08622913,0.00001955845,0.00005641836,0.003225402,0.00009051331,0.001002518,0.9010732,0.0001174454,0.007401048,0.00001175743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881278,0.006345396,0.001802425,0.0002304294,0.00009359937,0.00004833897,0.001385409,0.0000784164,0.001888077],"genre_scores_gemma":[0.989954,0.001736933,0.001347913,0.000106773,0.00001826511,0.0000673052,0.002458431,0.00001160947,0.004298714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002945786,"threshold_uncertainty_score":0.009854615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03064073371686233,"score_gpt":0.3296041094685865,"score_spread":0.2989633757517242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}