{"id":"W2061884616","doi":"10.1158/1538-7445.am10-1035","title":"Abstract 1035: Bcl2 is regulated by PKC and Akt and is associated with resistance to cisplatin in endometrial cancer cells.","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; Innovation and Economic Development Trois Rivières","funders":"","keywords":"Cisplatin; XIAP; Protein kinase B; Downregulation and upregulation; Cancer research; Apoptosis; MAPK/ERK pathway; Chemistry; Cell culture; Endometrial cancer; Kinase; Cancer; Biology; Medicine; Programmed cell death; Caspase; Internal medicine; Cell biology; Chemotherapy; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004537041,0.0001804348,0.0002942697,0.0001972146,0.0001673907,0.0001774112,0.0002195815,0.0001948882,0.004369719],"category_scores_gemma":[0.0001868858,0.0001639717,0.00002422628,0.0005422695,0.0001641169,0.0001118216,0.00009554252,0.0006016719,0.000005923244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000171514,"about_ca_system_score_gemma":0.0001343349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009974614,"about_ca_topic_score_gemma":0.002472697,"domain_scores_codex":[0.9980471,0.00003683881,0.0002853698,0.0005478058,0.0005946845,0.0004881888],"domain_scores_gemma":[0.9987617,0.0004067321,0.00009666817,0.0003108971,0.0001986577,0.0002253806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000436478,0.00006344448,0.009509359,0.00006433555,0.00004400994,0.000009835231,0.000542663,5.92038e-7,0.9725312,0.000003484619,0.01238256,0.004412048],"study_design_scores_gemma":[0.001909509,0.00003204549,0.025186,0.0003899865,0.000009548491,0.000001192295,0.00009203066,0.00002811881,0.9184325,0.00003246452,0.05359997,0.0002866783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951767,0.0005594134,8.168464e-7,0.001876622,0.00007313984,0.0001691657,0.0003616253,0.00002521061,0.00175734],"genre_scores_gemma":[0.9925915,0.0004926391,0.0000207519,0.0001464455,0.0001407079,0.0001551236,0.00001856027,0.00003846468,0.00639579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05409873,"threshold_uncertainty_score":0.9965404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03064073371686233,"score_gpt":0.3296041094685865,"score_spread":0.2989633757517242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}