{"id":"W2061900452","doi":"10.3899/jrheum.111171","title":"Timing and Magnitude of Initial Change in Disease Activity Score 28 Predicts the Likelihood of Achieving Low Disease Activity at 1 Year in Rheumatoid Arthritis Patients Treated with Certolizumab Pegol: A Post-hoc Analysis of the RAPID 1 Trial","year":2012,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"UCB Pharma; Amgen; Chugai Pharmaceutical; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Agency for Healthcare Research and Quality; AstraZeneca","keywords":"Medicine; Certolizumab pegol; Rheumatoid arthritis; Internal medicine; Post-hoc analysis; Methotrexate; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006244859,0.0009759198,0.002007898,0.0002261843,0.0002225076,0.0009013866,0.0006618277,0.0006323589,0.001670259],"category_scores_gemma":[0.005081818,0.0004590995,0.002651344,0.0001862251,0.0005517356,0.0007582324,0.0005973508,0.001719248,0.0002111728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003723117,"about_ca_system_score_gemma":0.0006708071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003887963,"about_ca_topic_score_gemma":0.0007101538,"domain_scores_codex":[0.9972414,0.0019051,0.0001330329,0.0003522822,0.0001811611,0.0001870173],"domain_scores_gemma":[0.9924015,0.004363378,0.001673264,0.0006662591,0.0002320074,0.0006636265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8439627,0.002289451,0.1290288,0.0003904923,0.00660269,0.0001517136,0.0001209107,0.002276004,0.003256566,0.0001081619,0.000692342,0.01112008],"study_design_scores_gemma":[0.167327,0.2864617,0.5067415,0.0001179779,0.01341405,0.0006433309,0.0002580267,0.01830358,0.00404958,0.0005822168,0.001953455,0.0001476639],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990128,0.0003950509,0.0001246637,0.00004694543,0.00002658672,0.0000543896,0.0001598979,0.000005463151,0.0001741933],"genre_scores_gemma":[0.9986487,0.0001198506,0.000248776,0.00004580543,0.00005494366,0.00009583579,0.000452108,0.000005154364,0.0003288694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006244859,"threshold_uncertainty_score":0.03302634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02112118902264415,"score_gpt":0.2805148793128899,"score_spread":0.2593936902902458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}