{"id":"W2061968952","doi":"10.1038/cgt.2012.79","title":"HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice","year":2012,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Tropism; Chinese hamster ovary cell; Virology; Virus; Biology; Cancer research; Genetic enhancement; In vitro; Oncolytic virus; Epidermal growth factor receptor; In vivo; Adenoviridae; Cell culture; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004728155,0.0001789786,0.0002480357,0.0001437911,0.00003435873,0.000008852342,0.0001367712,0.0001563798,0.00006790068],"category_scores_gemma":[0.00001205411,0.0001857039,0.00009270465,0.0003399954,0.00005960914,0.00002779503,0.00003024844,0.00014541,0.000001687945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001599798,"about_ca_system_score_gemma":0.0001780159,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01392864,"about_ca_topic_score_gemma":0.0007144401,"domain_scores_codex":[0.9985777,0.0002197522,0.0003748513,0.0002793593,0.0001961688,0.0003521793],"domain_scores_gemma":[0.999419,0.00001671567,0.0001899446,0.0002039419,0.0001042137,0.00006621794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004230229,0.00023969,0.01887212,0.0000260772,0.00006207813,2.860863e-7,0.000146001,0.00173353,0.9577817,3.077408e-7,0.0001271361,0.01678083],"study_design_scores_gemma":[0.001300251,0.000294294,0.01373096,0.00002761854,0.0000080524,0.000001704802,0.00003271374,0.0001021318,0.9841041,0.000003001989,0.0002195991,0.0001755491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883268,0.01089671,0.00003707217,0.00004119623,0.0001731535,0.000323692,0.0001798727,0.00000758728,0.00001390123],"genre_scores_gemma":[0.994391,0.00483559,0.00006496695,0.0000961215,0.0002547981,0.0001711771,0.00009893155,0.0000382575,0.00004920126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02632241,"threshold_uncertainty_score":0.9926377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01812863496368962,"score_gpt":0.3047587080421448,"score_spread":0.2866300730784552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}