{"id":"W2061981995","doi":"10.1093/oxfordjournals.jbchem.a022705","title":"Characterization of Recombinant Human DNA Topoisomerase III  Activity Expressed in Yeast","year":2000,"lang":"en","type":"article","venue":"The Journal of Biochemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint Paul University","funders":"","keywords":"DNA supercoil; Topoisomerase; Recombinant DNA; Mutant; DNA; Biology; Molecular biology; Yeast; Biochemistry; Enzyme; DNA gyrase; Gene; Saccharomyces cerevisiae; Escherichia coli; DNA replication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002160996,0.0004620637,0.0002948028,0.0002720493,0.00008868773,0.0003732095,0.0001875997,0.0001887309,0.0008579853],"category_scores_gemma":[0.0003162653,0.0001526735,0.0002896736,0.0003206279,0.0001252399,0.0001339863,0.0001035767,0.0005506526,0.0007947796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002911002,"about_ca_system_score_gemma":0.0002005849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077842,"about_ca_topic_score_gemma":0.0005999237,"domain_scores_codex":[0.9998853,0.00001966571,0.00001525116,0.00002403622,0.00003694086,0.00001879919],"domain_scores_gemma":[0.9998616,0.0000309041,0.00002105524,0.00002520078,0.00003530523,0.00002593145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004604898,0.00001360651,0.0001700525,0.00003174029,0.00000526956,0.00004760589,0.00001482717,0.00005456242,0.9988494,0.00007251767,0.00002477088,0.0006695709],"study_design_scores_gemma":[0.00001928372,0.0001276569,0.002539723,0.00001218261,0.0000194675,0.0003430027,0.00003386833,0.0006784074,0.9919167,0.00007354593,0.004229982,0.000006089283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654398,0.004557818,0.02302388,0.000320151,0.00009284728,0.0001296501,0.00397103,0.0002232179,0.002241631],"genre_scores_gemma":[0.9604355,0.00280583,0.01606715,0.00007325975,0.00003711611,0.00007784966,0.01389478,0.00008039836,0.006527986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001077842,"threshold_uncertainty_score":0.002870202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00864798578882223,"score_gpt":0.242089614810106,"score_spread":0.2334416290212838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}