{"id":"W2061981995","doi":"10.1093/oxfordjournals.jbchem.a022705","title":"Characterization of Recombinant Human DNA Topoisomerase III  Activity Expressed in Yeast","year":2000,"lang":"en","type":"article","venue":"The Journal of Biochemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint Paul University","funders":"","keywords":"DNA supercoil; Topoisomerase; Recombinant DNA; Mutant; DNA; Biology; Molecular biology; Yeast; Biochemistry; Enzyme; DNA gyrase; Gene; Saccharomyces cerevisiae; Escherichia coli; DNA replication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002519621,0.0000877411,0.0001423928,0.00002069155,0.00003229872,0.00000657158,0.0001973621,0.00008235654,0.00009239935],"category_scores_gemma":[0.000005673802,0.00006739399,0.00007091282,0.00006089662,0.00004377947,0.000004503972,0.00002392857,0.0001045859,5.376395e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001737558,"about_ca_system_score_gemma":0.00005807833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001248634,"about_ca_topic_score_gemma":0.000003774155,"domain_scores_codex":[0.9994151,0.00003851355,0.0002471798,0.00008246278,0.0001076558,0.0001090704],"domain_scores_gemma":[0.9994593,0.000004198299,0.0002318478,0.0002115707,0.00005482936,0.00003828992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003750731,0.0001177469,0.0000234033,0.00001468669,0.00002552055,0.000001633305,0.00006939033,0.000005599048,0.9925275,0.000002648616,0.00004054885,0.006796221],"study_design_scores_gemma":[0.0007671568,0.0001575066,0.0006791532,0.00004384234,0.00001869273,0.00002769101,0.00004124813,0.000006270448,0.9958649,0.00005245836,0.002266008,0.0000750242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993063,0.0001186403,0.00008701236,0.0001340731,0.00007981774,0.00005140705,0.00001058239,0.000001221963,0.0002109289],"genre_scores_gemma":[0.9984034,0.0005770918,0.00001466898,0.00006640908,0.0001298573,0.000001480934,0.00001394411,0.000009700611,0.0007834117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006721197,"threshold_uncertainty_score":0.2748247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00864798578882223,"score_gpt":0.242089614810106,"score_spread":0.2334416290212838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}