{"id":"W2061990109","doi":"10.1515/bc.2002.207","title":"Evidence That E-Box Promoter Elements and MyoD Transcription Factors Play a Role in the Induction of Cathepsin B Gene Expression during Human Myoblast Differentiation","year":2002,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; University of Washington","keywords":"MyoD; Myogenin; Myogenesis; Molecular biology; Biology; Transfection; Transcription factor; MyoD Protein; Cathepsin H; Promoter; Myocyte; Transcription (linguistics); Cathepsin; Cathepsin E; Cathepsin L; Cathepsin B; Gene expression; Gene; Cell biology; Cathepsin O; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008769846,0.0001213221,0.0001053008,0.00001220068,0.00007968208,0.000008256165,0.0001214105,0.0002190606,0.00006946931],"category_scores_gemma":[0.00004632975,0.00007825986,0.00004623033,0.00003790137,0.00009074499,0.000008019617,0.00003998024,0.0001056454,3.996382e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007897596,"about_ca_system_score_gemma":0.000002704115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007486171,"about_ca_topic_score_gemma":0.000003116033,"domain_scores_codex":[0.9992679,0.00007586713,0.0001679637,0.0002740859,0.00007525361,0.0001389197],"domain_scores_gemma":[0.9996854,0.00001128897,0.0001096805,0.0001544035,0.00001385593,0.00002538957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005534959,0.0001173757,0.05745299,0.00002862385,0.000006443174,2.483663e-7,0.0002405521,0.000001700069,0.9419336,9.165382e-7,0.000006682032,0.0001554932],"study_design_scores_gemma":[0.0002589037,0.00008772288,0.2391374,0.00002724906,0.000004443307,0.000001908858,0.0002033589,0.000005229916,0.7601312,0.00005755204,0.0000105254,0.00007449479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999109,0.00060161,0.00003035577,0.00003267117,0.00001529017,0.0001348105,0.000007375581,0.000006233427,0.00006263341],"genre_scores_gemma":[0.9994888,0.0002680598,0.00002621603,0.00001642538,0.00004606766,0.00002737449,0.00009977038,0.000004464348,0.00002283796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1818024,"threshold_uncertainty_score":0.3191344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04573869707724317,"score_gpt":0.2483158770221229,"score_spread":0.2025771799448798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}