{"id":"W2061990109","doi":"10.1515/bc.2002.207","title":"Evidence That E-Box Promoter Elements and MyoD Transcription Factors Play a Role in the Induction of Cathepsin B Gene Expression during Human Myoblast Differentiation","year":2002,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; University of Washington","keywords":"MyoD; Myogenin; Myogenesis; Molecular biology; Biology; Transfection; Transcription factor; MyoD Protein; Cathepsin H; Promoter; Myocyte; Transcription (linguistics); Cathepsin; Cathepsin E; Cathepsin L; Cathepsin B; Gene expression; Gene; Cell biology; Cathepsin O; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261164,0.0001623274,0.00008725154,0.0001516436,0.0001009714,0.0001549134,0.00008208596,0.0001819581,0.001898716],"category_scores_gemma":[0.0001937994,0.0001492967,0.0001233808,0.0001036646,0.0001730804,0.000114238,0.0001554148,0.0002649202,0.0006075213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000176572,"about_ca_system_score_gemma":0.0001867005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005363265,"about_ca_topic_score_gemma":0.0008450437,"domain_scores_codex":[0.9999282,0.00001036977,0.000006008941,0.00001887919,0.00001982245,0.00001679906],"domain_scores_gemma":[0.9998637,0.00004849857,0.00002777527,0.00001511135,0.00001668924,0.00002811965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001395964,0.00001407973,0.000917279,0.00004374491,0.000002078261,0.00008162866,0.00002093127,0.00001707864,0.997375,0.00007884107,0.00002498557,0.001284861],"study_design_scores_gemma":[0.00004111865,0.0001635237,0.05537756,0.00002223848,0.00001747479,0.001379149,0.00005831645,0.0003417884,0.9390493,0.00009840925,0.003446782,0.000004402953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906094,0.002454021,0.004210985,0.0001391465,0.00001451442,0.00002066012,0.0005326651,0.00004547753,0.001973137],"genre_scores_gemma":[0.9854771,0.001676399,0.005941484,0.00009298365,0.00001059458,0.00003898638,0.001672402,0.0000142208,0.005075878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001898716,"threshold_uncertainty_score":0.006351829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04573869707724317,"score_gpt":0.2483158770221229,"score_spread":0.2025771799448798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}