{"id":"W2061996376","doi":"10.1002/mds.22690","title":"A longitudinal program for biomarker development in Parkinson's disease: A feasibility study","year":2009,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Biomarker; Clinical trial; Medicine; Oncology; Precept; Parkinson's disease; Cohort; Internal medicine; Disease; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02688185,0.0009325831,0.0006710546,0.001320048,0.002208817,0.00134428,0.001379312,0.001099087,0.003496461],"category_scores_gemma":[0.0229889,0.0007510311,0.0008217691,0.001256683,0.0008098188,0.002066178,0.002821042,0.001542581,0.002035259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00118531,"about_ca_system_score_gemma":0.006672403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007726226,"about_ca_topic_score_gemma":0.00721672,"domain_scores_codex":[0.9874852,0.009369238,0.0005226053,0.0007929706,0.001016694,0.0008132771],"domain_scores_gemma":[0.9789104,0.004697203,0.002034235,0.004032975,0.004500834,0.005824401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05885605,0.03206993,0.7803875,0.0003159711,0.0004913739,0.001271788,0.003626001,0.0008255573,0.00429453,0.002314505,0.01074641,0.1048003],"study_design_scores_gemma":[0.02693907,0.1435068,0.7938991,0.0002419548,0.0004782187,0.001328435,0.00238173,0.004730334,0.001534521,0.001916794,0.02288741,0.0001556086],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9447827,0.0004813589,0.00959797,0.00187353,0.0001653244,0.03219259,0.005922122,0.0002561463,0.004728295],"genre_scores_gemma":[0.8934546,0.0004371171,0.04461511,0.001478125,0.0002557166,0.04920143,0.007457293,0.0001068747,0.002993614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02688185,"threshold_uncertainty_score":0.1421666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03788619282469888,"score_gpt":0.3299107926715057,"score_spread":0.2920245998468068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}