{"id":"W2061996376","doi":"10.1002/mds.22690","title":"A longitudinal program for biomarker development in Parkinson's disease: A feasibility study","year":2009,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Biomarker; Clinical trial; Medicine; Oncology; Precept; Parkinson's disease; Cohort; Internal medicine; Disease; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002743868,0.0003030984,0.0003416928,0.00017942,0.0001228809,0.00003649689,0.0001015419,0.0000435144,0.00006542949],"category_scores_gemma":[0.00004502007,0.0002629076,0.0001526421,0.0002859017,0.00002652523,0.00007906938,0.00003394982,0.00006899329,0.000009680922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003733601,"about_ca_system_score_gemma":0.0001884257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003939659,"about_ca_topic_score_gemma":0.0003581606,"domain_scores_codex":[0.9979675,0.00004034725,0.0003682557,0.0006949638,0.0004160041,0.0005129654],"domain_scores_gemma":[0.9991519,0.00001825308,0.00007593584,0.0003822308,0.00005039847,0.0003213126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001686061,0.02310796,0.8125893,0.00005940826,0.0001632884,0.00006929348,0.0001769499,0.000002987074,0.00002810552,0.00005958019,0.0003311733,0.1617258],"study_design_scores_gemma":[0.009292648,0.001572298,0.9676303,0.00005996557,0.0001487548,1.1168e-7,0.0002737057,0.0002887959,0.00004253627,0.004261699,0.01618153,0.0002476601],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891931,0.00046351,0.0004292926,0.001306553,0.00007445185,0.008074887,0.0000208457,0.0001321304,0.0003051765],"genre_scores_gemma":[0.994365,0.00002251997,0.002216255,0.0008834769,0.00001571722,0.002166809,0.0001075107,0.00002252519,0.0002001512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1614782,"threshold_uncertainty_score":0.9999823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03788619282469888,"score_gpt":0.3299107926715057,"score_spread":0.2920245998468068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}