{"id":"W2062000072","doi":"10.12688/f1000research.6213.1","title":"Signaling mechanism by the Staphylococcus aureus two-component system LytSR: role of acetyl phosphate in bypassing the cell membrane electrical potential sensor LytS","year":2015,"lang":"en","type":"preprint","venue":"F1000Research","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Operon; Cell biology; Genetics; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002478508,0.0005027181,0.0008674732,0.000255515,0.0004755782,0.0001564901,0.001526109,0.0006676405,0.000138759],"category_scores_gemma":[0.00006508734,0.000322059,0.0003292496,0.0002991931,0.0005849212,0.00007634169,0.001589474,0.002850295,0.0001306641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003277985,"about_ca_system_score_gemma":0.0005193526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004649352,"about_ca_topic_score_gemma":0.00004145778,"domain_scores_codex":[0.9951798,0.001785345,0.0007901394,0.0007273671,0.000361924,0.001155431],"domain_scores_gemma":[0.9977854,0.0005294165,0.0004324557,0.0008661936,0.0003184972,0.00006800737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005206848,0.0002189335,0.0000260377,0.0002291361,0.0002441006,0.00002552313,0.0009747014,0.002346121,0.9901618,0.0007202512,0.003842796,0.000689944],"study_design_scores_gemma":[0.001407531,0.0001555692,0.0000226269,0.0002774455,0.0001108988,0.00002557344,0.0041174,0.002573445,0.9886816,0.0004985373,0.001759643,0.0003697613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977604,0.01723586,0.0005063874,0.0006180152,0.0007653085,0.001818959,0.0004398555,0.000100973,0.0009106803],"genre_scores_gemma":[0.9971501,0.0003370381,0.0000885496,0.00005500721,0.0001607845,0.0001022917,0.0002129942,0.00007826712,0.001814955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01954616,"threshold_uncertainty_score":0.9999232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487149098700253,"score_gpt":0.2516159817661136,"score_spread":0.236744490779111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}