{"id":"W2062023215","doi":"10.1038/sj.cdd.4401451","title":"Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease","year":2004,"lang":"en","type":"review","venue":"Cell Death and Differentiation","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":407,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Hamilton Health Sciences; McMaster University Medical Centre","funders":"National Institutes of Health; National Institute of Neurological Disorders and Stroke; Office of Research and Development; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Hyperhomocysteinemia; Homocysteine; Endothelial dysfunction; Methylenetetrahydrofolate reductase; Cystathionine beta synthase; Endocrinology; Internal medicine; Unfolded protein response; Oxidative stress; B vitamins; Biology; Medicine; Methionine; Endoplasmic reticulum; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007060872,0.0001953913,0.0006955577,0.0002524281,0.00002741709,0.00001742131,0.00003286923,0.0001644313,0.00003854329],"category_scores_gemma":[0.00002957095,0.0001454863,0.0001044905,0.0001122324,0.00003348561,0.00004632893,0.00003370473,0.0001845028,0.000008073143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007473072,"about_ca_system_score_gemma":0.0001638551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006134193,"about_ca_topic_score_gemma":0.000006529562,"domain_scores_codex":[0.999037,0.0000529276,0.0003094039,0.0002634866,0.0001765457,0.0001606655],"domain_scores_gemma":[0.99951,0.00004246023,0.0001078849,0.0001579496,0.00003045903,0.0001512099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001673809,0.0004823921,0.007627339,0.07721598,0.00008824527,0.00002461038,0.0001423663,6.509155e-7,0.001142209,0.0002335883,0.00000366624,0.9128715],"study_design_scores_gemma":[0.04023626,0.005130232,0.5571811,0.173436,0.01989401,0.0002658285,0.0004078807,0.002993687,0.001709757,0.005107502,0.1899654,0.003672407],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08906973,0.909852,0.00001688028,0.000003834122,0.0000388479,0.0006691466,0.00002403987,0.00001042883,0.0003150394],"genre_scores_gemma":[0.1571197,0.8422315,0.00001961655,0.000003012106,0.00005547778,0.00002928178,0.000216026,0.00002083608,0.0003045384],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9091992,"threshold_uncertainty_score":0.5932759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02382621134151287,"score_gpt":0.2869417616707303,"score_spread":0.2631155503292175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}