{"id":"W2062049660","doi":"10.1107/s0108767305089683","title":"Structures of 5-methylthioribose kinase: catalytic mechanism and drug design","year":2005,"lang":"en","type":"article","venue":"Acta Crystallographica Section A Foundations of Crystallography","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Mechanism (biology); Drug; Catalysis; Combinatorial chemistry; Chemistry; Computational biology; Pharmacology; Biochemistry; Medicine; Biology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004416703,0.000262491,0.000295591,0.0006390365,0.0001631378,0.00003667504,0.0003104111,0.0002593165,0.0000380024],"category_scores_gemma":[0.0001521194,0.0002582083,0.0002872211,0.0008130625,0.0006716581,0.00002733519,0.0001774682,0.0002137288,1.044543e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001016365,"about_ca_system_score_gemma":0.00009592064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006873905,"about_ca_topic_score_gemma":0.00008544653,"domain_scores_codex":[0.9981504,0.0001748802,0.0004952688,0.0005057325,0.0003524057,0.0003213192],"domain_scores_gemma":[0.9986211,0.00006267731,0.0002605633,0.0005316713,0.0003556159,0.0001683548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001552832,0.0001794097,0.0003723712,0.00007686589,0.0002238517,7.042801e-7,0.000070935,0.00004132601,0.9957657,0.001568202,0.0004991662,0.001046121],"study_design_scores_gemma":[0.002666496,0.001468789,0.005493162,0.00007738602,0.0002959177,0.00009864441,0.0004581595,0.0002047551,0.8611879,0.02077093,0.1062967,0.0009811862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647061,0.0009297499,0.03263878,0.000535619,0.0000979478,0.0005775124,0.00005316363,0.00003626441,0.0004248636],"genre_scores_gemma":[0.9881655,0.0006860037,0.01063666,0.00008294828,0.0001009705,0.00004796754,0.000180855,0.00003394012,0.00006515087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1345779,"threshold_uncertainty_score":0.999987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173508004240389,"score_gpt":0.2622357925091577,"score_spread":0.2505007124667538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}