{"id":"W2062133434","doi":"10.1096/fj.00-0678fje","title":"The cytoplasmic truncated receptor tyrosine kinase ALK‐ homodimer immortalizes and cooperates with ras in cellular transformation","year":2001,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Transformation (genetics); Tyrosine kinase; Cell biology; ROR1; Receptor tyrosine kinase; Chemistry; Cytoplasm; Receptor; Cancer research; Kinase; Molecular biology; Biology; Platelet-derived growth factor receptor; Signal transduction; Gene; Biochemistry; Growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00051001,0.0001626619,0.000197459,0.00009145132,0.0003387839,0.00009171294,0.0001003679,0.00006879576,0.0001013431],"category_scores_gemma":[0.00003419115,0.00008105437,0.00005056022,0.0003486939,0.0001739197,0.0001260999,0.00001021392,0.0005379799,0.00001941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000095972,"about_ca_system_score_gemma":0.0001537154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006215219,"about_ca_topic_score_gemma":0.0001215332,"domain_scores_codex":[0.9988981,0.0001197082,0.0003083948,0.0001218967,0.0002714246,0.000280439],"domain_scores_gemma":[0.9994249,0.0000527948,0.0001043059,0.0001909046,0.0001087717,0.0001183729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00207122,0.00008669503,0.001957563,0.0000157367,0.0001422113,0.000278498,0.00175846,0.0004966248,0.9866004,0.0001203358,0.0005837432,0.005888502],"study_design_scores_gemma":[0.01049177,0.000990588,0.004250087,0.0005179975,0.0003514531,0.006274594,0.001724734,0.003602752,0.9596694,0.00009142406,0.01172032,0.0003148529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905854,0.004470247,0.0006842773,0.003177674,0.0001351835,0.0003751297,0.000006054158,0.00002230064,0.0005437449],"genre_scores_gemma":[0.9958582,0.003424787,0.00006958989,0.000211486,0.00009769321,0.00001211494,0.00002347194,0.00002685132,0.0002757931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02693099,"threshold_uncertainty_score":0.3305301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009452904185540005,"score_gpt":0.2204371434383481,"score_spread":0.2109842392528081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}