{"id":"W2062137938","doi":"10.1073/pnas.0906387106","title":"Preerythrocytic, live-attenuated <i>Plasmodium falciparum</i> vaccine candidates by design","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Malaria Research and Control","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Foundation for the National Institutes of Health","keywords":"Biology; Plasmodium falciparum; Virology; Malaria; Attenuated vaccine; Gametocyte; Malaria vaccine; Anopheles; Gene; Plasmodium (life cycle); Circumsporozoite protein; Parasite hosting; Genetics; Immunology; Virulence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002307145,0.0004973485,0.0003343044,0.0001791593,0.0001535438,0.0003492168,0.0004409374,0.00030148,0.001297557],"category_scores_gemma":[0.0001811579,0.0002366393,0.0002158858,0.0001203357,0.0002299597,0.0003104648,0.0002333296,0.0005864875,0.0007794771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002352901,"about_ca_system_score_gemma":0.0002116614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001602152,"about_ca_topic_score_gemma":0.0002796841,"domain_scores_codex":[0.9998369,0.00004228548,0.00001577951,0.00003274213,0.00003912737,0.00003325368],"domain_scores_gemma":[0.9999111,0.000009225162,0.00003232288,0.00001295428,0.00001534254,0.00001902866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001380831,0.0000517185,0.0001722826,0.0001111442,0.000006243438,0.00005868628,0.00001527718,0.0004404431,0.9939546,0.0009615485,0.0001563137,0.003933709],"study_design_scores_gemma":[0.00005926197,0.001807004,0.001015174,0.00001365038,0.00004384468,0.0005299986,0.0000211161,0.001721551,0.978766,0.0002548659,0.01575894,0.00000861624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9093384,0.0044536,0.07697298,0.0005073289,0.0001286165,0.000770396,0.001569725,0.0004289415,0.005830211],"genre_scores_gemma":[0.9304132,0.003494402,0.05550502,0.0001943303,0.00002578185,0.0006461152,0.00198024,0.0001006368,0.007640395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001297557,"threshold_uncertainty_score":0.004340768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03437381048896542,"score_gpt":0.3092767869540617,"score_spread":0.2749029764650963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}