{"id":"W2062137938","doi":"10.1073/pnas.0906387106","title":"Preerythrocytic, live-attenuated <i>Plasmodium falciparum</i> vaccine candidates by design","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Malaria Research and Control","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Foundation for the National Institutes of Health","keywords":"Biology; Plasmodium falciparum; Virology; Malaria; Attenuated vaccine; Gametocyte; Malaria vaccine; Anopheles; Gene; Plasmodium (life cycle); Circumsporozoite protein; Parasite hosting; Genetics; Immunology; Virulence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001242448,0.0001094245,0.0002365634,0.0001412486,0.0001491731,0.0000254798,0.0005473314,0.00008569344,0.00005149735],"category_scores_gemma":[0.000893468,0.00006673288,0.00007171866,0.0006225511,0.0002726536,0.0002894535,0.0000539772,0.0002159323,0.000005715096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004552732,"about_ca_system_score_gemma":0.0001005107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001254411,"about_ca_topic_score_gemma":6.160501e-8,"domain_scores_codex":[0.9977759,0.000009530189,0.0003057792,0.0002398315,0.001406522,0.0002624836],"domain_scores_gemma":[0.9990793,0.0001330726,0.0002430951,0.00001047406,0.0004351709,0.00009883311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005326344,0.000201453,0.004634155,0.00007887111,0.00005265011,4.507806e-8,0.0001050327,0.00004607936,0.9271912,0.00707949,0.05943247,0.0006459403],"study_design_scores_gemma":[0.002203451,0.0009896577,0.07997748,0.000216427,0.00007140911,0.00004231591,0.0001157426,0.01077289,0.8815992,0.02301288,0.0008407615,0.0001577716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8229948,0.001639304,0.00003621114,0.1536496,0.00002757181,0.001657119,0.0000605237,0.00006629748,0.01986864],"genre_scores_gemma":[0.9969376,0.00008764739,0.0009761897,0.001251704,0.0000604266,0.0000120036,4.811802e-7,0.000003530351,0.0006704376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1739428,"threshold_uncertainty_score":0.2721288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03437381048896542,"score_gpt":0.3092767869540617,"score_spread":0.2749029764650963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}