{"id":"W2062158521","doi":"10.1016/j.brainres.2006.02.122","title":"Loss of nicastrin elicits an apoptotic phenotype in mouse embryos","year":2006,"lang":"en","type":"article","venue":"Brain Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Children’s Health Research Institute; Western University; Occupational Cancer Research Centre; Hospital for Sick Children; London Health Sciences Centre; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Nicastrin; Presenilin; Biology; Notch signaling pathway; Phenotype; Programmed cell death; Cell biology; Neurodegeneration; Embryonic stem cell; Apoptosis; Gamma secretase; Alzheimer's disease; Endocrinology; Internal medicine; Genetics; Signal transduction; Disease; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002830472,0.0004967632,0.0003233649,0.0008714225,0.0003213508,0.0003922713,0.000489118,0.0008217496,0.001996095],"category_scores_gemma":[0.0002955779,0.0004207298,0.0003714926,0.0001827456,0.000457873,0.0003124058,0.0004206073,0.001395035,0.0006538829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006842812,"about_ca_system_score_gemma":0.0002541038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001288475,"about_ca_topic_score_gemma":0.002456762,"domain_scores_codex":[0.9996487,0.00005720742,0.00004560134,0.00006650628,0.0001062107,0.00007580862],"domain_scores_gemma":[0.9995655,0.000136783,0.000118945,0.00005582525,0.00002734198,0.00009568093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001395642,0.00001880744,0.0001007626,0.00001634955,0.000005211174,0.0002152716,0.00002913131,0.00008194665,0.9987362,0.0002064261,0.00002862952,0.0004217392],"study_design_scores_gemma":[0.0000305052,0.0001973287,0.002550384,0.00001130557,0.00001695425,0.0005791291,0.00005657338,0.0008082352,0.9939929,0.00009573037,0.00165504,0.000006009986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887539,0.001449647,0.00396266,0.0003016048,0.00007351256,0.00006807144,0.0007233894,0.0001757806,0.004491263],"genre_scores_gemma":[0.9840124,0.0009357462,0.002486307,0.0001158269,0.00001467256,0.00006484581,0.0006285171,0.00009187016,0.01164979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001996095,"threshold_uncertainty_score":0.006677628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07432201497401249,"score_gpt":0.4056786763278904,"score_spread":0.3313566613538779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}