{"id":"W2062165579","doi":"10.1007/s10549-013-2626-7","title":"Exosomal pMHC-I complex targets T cell-based vaccine to directly stimulate CTL responses leading to antitumor immunity in transgenic FVBneuN and HLA-A2/HER2 mice and eradicating trastuzumab-resistant tumor in athymic nude mice","year":2013,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"CTL*; HER2/neu; Biology; Immunology; Cytotoxic T cell; Immune system; Cancer research; CD8; Trastuzumab; Immunotherapy; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006605669,0.0004141981,0.0006599222,0.0007265059,0.00050561,0.0001077996,0.0002316638,0.0001195544,0.0002748878],"category_scores_gemma":[0.00005720061,0.0003500822,0.00005898109,0.0005298169,0.0002398849,0.0001696731,0.0001025508,0.0004192915,0.00004953053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004678613,"about_ca_system_score_gemma":0.0003037644,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03189039,"about_ca_topic_score_gemma":0.005243677,"domain_scores_codex":[0.9965214,0.001088245,0.0005103096,0.0007020735,0.0001169005,0.001061064],"domain_scores_gemma":[0.9985105,0.0008149045,0.00007744945,0.0003233429,0.0001103152,0.0001634353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01692485,0.0007241226,0.02176876,0.00007781458,0.0001358118,0.00005629619,0.002307266,0.00003909513,0.9411622,0.000008499169,0.00006752501,0.01672772],"study_design_scores_gemma":[0.008440287,0.002379409,0.7939799,0.0003698189,0.00002627721,0.0001215113,0.0007906319,0.00005053643,0.191843,0.00001568025,0.001583016,0.000399977],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755951,0.02040284,0.000008920883,0.001944399,0.00004956658,0.00168291,0.0002457668,0.00003514316,0.00003538208],"genre_scores_gemma":[0.9969148,0.00137268,0.0002108064,0.000184059,0.00001625664,0.0006248639,0.00003723898,0.00004480291,0.0005945148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7722111,"threshold_uncertainty_score":0.9998951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03457243733282276,"score_gpt":0.3248644562996134,"score_spread":0.2902920189667906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}