{"id":"W2062165579","doi":"10.1007/s10549-013-2626-7","title":"Exosomal pMHC-I complex targets T cell-based vaccine to directly stimulate CTL responses leading to antitumor immunity in transgenic FVBneuN and HLA-A2/HER2 mice and eradicating trastuzumab-resistant tumor in athymic nude mice","year":2013,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"CTL*; HER2/neu; Biology; Immunology; Cytotoxic T cell; Immune system; Cancer research; CD8; Trastuzumab; Immunotherapy; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002181824,0.0004869263,0.0002766148,0.000244322,0.0001504722,0.0002982103,0.0002616549,0.0004829657,0.001337323],"category_scores_gemma":[0.0001489553,0.0002036373,0.0002266303,0.0001093919,0.0002273956,0.0002813589,0.0001669753,0.001573944,0.0004981727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003352034,"about_ca_system_score_gemma":0.0002043323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003261561,"about_ca_topic_score_gemma":0.0003022135,"domain_scores_codex":[0.9997411,0.0000385672,0.00002108036,0.0000603,0.00004434115,0.00009461792],"domain_scores_gemma":[0.99986,0.0000355829,0.00003005871,0.0000232618,0.00001279774,0.00003826512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003846957,0.0001710601,0.00006791665,0.00002122507,0.000005332021,0.00003389199,0.0000131674,0.0001706165,0.9980704,0.0001774843,0.00008995675,0.0007942193],"study_design_scores_gemma":[0.0001240755,0.0008424651,0.0009293198,0.000005203775,0.00001907703,0.0001538051,0.00001432638,0.002367619,0.9942697,0.00007155584,0.001199067,0.000003722142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929998,0.0005859153,0.003603221,0.0001957966,0.0001091631,0.00008434505,0.0003155674,0.0001233718,0.001982848],"genre_scores_gemma":[0.9951847,0.0002531808,0.001623344,0.00008532876,0.00004281186,0.00007820281,0.000397778,0.00002679032,0.002307914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337323,"threshold_uncertainty_score":0.004473805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03457243733282276,"score_gpt":0.3248644562996134,"score_spread":0.2902920189667906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}