{"id":"W2062204664","doi":"10.1089/hum.2012.179","title":"Gene Therapy for Mucopolysaccharidosis Type VI Is Effective in Cats Without Pre-Existing Immunity to AAV8","year":2012,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Immunity; Genetic enhancement; Lysosomal storage disease; Biology; Cellular immunity; Immunology; Enzyme replacement therapy; Immune system; Virology; Systemic administration; Transduction (biophysics); Antibody; Gene; Medicine; Disease; Enzyme; Genetics; Internal medicine; In vivo","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001123881,0.0003998757,0.0003782616,0.0001901634,0.0003203957,0.00005100354,0.0005682121,0.0002379862,0.0001546071],"category_scores_gemma":[0.00005350437,0.0003785563,0.000174083,0.0003131273,0.00009391684,0.00001509632,0.0001213728,0.0002310849,0.00003544782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001007805,"about_ca_system_score_gemma":0.0001121609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002392924,"about_ca_topic_score_gemma":0.0002066899,"domain_scores_codex":[0.9975564,0.0003442325,0.0003501748,0.0005796739,0.0002681264,0.0009013318],"domain_scores_gemma":[0.9984241,0.00005634971,0.000118239,0.0009267844,0.0002319462,0.0002426529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006354213,0.0004624531,0.007452096,0.000009706462,0.000198985,7.515627e-7,0.001838197,0.00003336882,0.959182,0.000006827037,0.0007018467,0.02375957],"study_design_scores_gemma":[0.002690864,0.006866828,0.01718801,0.00001478188,0.000007515516,0.000005122173,0.00005245866,0.00002232022,0.9676441,0.00009818182,0.004964383,0.0004454246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98965,0.007230472,0.0003202949,0.0001001058,0.000264599,0.002164161,0.00003576596,0.0000382962,0.000196307],"genre_scores_gemma":[0.9939197,0.001214011,0.0007050992,0.001595865,0.0008096797,0.0006818256,0.0001395356,0.000136281,0.000797972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02331415,"threshold_uncertainty_score":0.9998667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05575788548302395,"score_gpt":0.3816851048815918,"score_spread":0.3259272193985678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}