{"id":"W2062204664","doi":"10.1089/hum.2012.179","title":"Gene Therapy for Mucopolysaccharidosis Type VI Is Effective in Cats Without Pre-Existing Immunity to AAV8","year":2012,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Immunity; Genetic enhancement; Lysosomal storage disease; Biology; Cellular immunity; Immunology; Enzyme replacement therapy; Immune system; Virology; Systemic administration; Transduction (biophysics); Antibody; Gene; Medicine; Disease; Enzyme; Genetics; Internal medicine; In vivo","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004014279,0.0003820662,0.0006197616,0.0004831209,0.0002858053,0.0005502179,0.000448784,0.0008009959,0.001366992],"category_scores_gemma":[0.0004191667,0.0001880019,0.0002811701,0.0001562703,0.0006601611,0.0004629258,0.0002692175,0.0006861669,0.0003739088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005577631,"about_ca_system_score_gemma":0.0004526534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001649109,"about_ca_topic_score_gemma":0.002583476,"domain_scores_codex":[0.9996082,0.00007201746,0.00003644749,0.0001104641,0.00009706372,0.00007576356],"domain_scores_gemma":[0.9996632,0.00006462884,0.00009847843,0.00004298923,0.00002749341,0.0001032378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002506437,0.0002200952,0.0004074285,0.00009332143,0.00001186596,0.0001728432,0.00005733782,0.0001385393,0.9951539,0.0002183768,0.0001270805,0.003148562],"study_design_scores_gemma":[0.000331568,0.01470888,0.009569403,0.00009670699,0.00008886418,0.002992708,0.000134178,0.004235663,0.9580832,0.000259032,0.009465327,0.0000344451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958279,0.0004636825,0.001841725,0.0001524179,0.00002768021,0.0001376313,0.0001737198,0.0001009568,0.001274205],"genre_scores_gemma":[0.9898942,0.0006972619,0.005479076,0.00007864999,0.00001236712,0.0002303123,0.0004673706,0.00003331088,0.003107471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001649109,"threshold_uncertainty_score":0.004573107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05575788548302395,"score_gpt":0.3816851048815918,"score_spread":0.3259272193985678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}